By Richard B. Gibson As many will remember, in 2018, now infamous Chinese researcher He Jiankui announced on YouTube that, using CRISPR/Cas9, he had been (jointly) responsible for creating gene-edited twins called Lulu & Nana. He and his team’s purported aim was to engineer the twins to be resistant to HIV infection. Two days after […]
Category: Gene editing
Queering the genome: epigenome editing for biological lesbian motherhood
By Adrian Villalba. In the thrilling frontier of reproductive technologies, a ground-breaking approach aims to shake the foundations of conventional norms – it’s called epigenome editing. Imagine a world where same-sex couples can have genetically related children without the traditional genetic hurdles. Welcome to the era of “queering the genome”. This revolutionary technique bypasses the […]
“Ethics first” reform for medical research in China: from reactive to proactive
By Jingyi Xu, Zhongxuan Liu, Jiayou Shi, Yue Wang. The 2018 CRISPR-babies incident, involving the controversial editing of human genomes, significantly impacted China’s approach to the ethics governance in medical research. The event underscored the need for a shift from a reactive, post hoc framework to a more proactive and anticipatory model. As a global […]
Addressing the current research gap on the ethical evaluation of epigenome editing
By Karla Alex and Eva C. Winkler. Epigenome editing is a new research tool that has many potential applications in medicine but has not yet received much attention from ethicists. Our new article in Journal of Medical Ethics addresses this gap and proposes criteria for the assessments of risks of genome editing versus epigenome editing. […]
Why we can almost guarantee that genetic enhancement will never be fairly distributed
By Sinead Prince. We’ve been discussing the possibility of genetic enhancement, and the ethics of such technology, for some time now. Many people are quite cautious about the idea of genetically modifying embryos as well as adults, but others have begun waving the green flag rigorously. Genetic enhancement is the modification of genes using technologies […]
Developing a practical resource to improve the ethical standing of gene therapy trials
By Rosie Munday, Hugh Davies and Stephanie Jones with Oxford “A” Health Research Authority Research Ethics Committee Oxford “A” NHS REC is one of the four UK Research Ethics Committees flagged to review gene therapy proposals. Following the philosopher Mary Warnock’s sage advice “I do not believe you can make moral judgements unless, as far […]
Heritable human genome editing: Who decides? Science or society?
By Françoise Baylis Many describe the move from bench to bedside (from basic science to therapeutic or preventive applications) as a sprint – a short quick race. Others suggest that the race (such as it is) is more like hurdles given the many obstacles that must be overcome. Still others prefer to think of the […]
Is the “serious” factor in germline modification really relevant? A response to Kleiderman, Ravitsky and Knoppers
By Iñigo de Miguel Beriain Is the “serious” factor in germline modification relevant? This seems a relevant question in the germline gene editing debate. Of course, at first glance, one tends to choose an affirmative answer immediately. It seems common sense to think that sophisticated technology should be used only when we are faced with […]
He Jiankui’s Genetic Misadventure: Why Him? Why China?
By Jing-Bao Nie This post first appeared on The Hastings Center Forum on 5 December, 2018. The birth of gene-edited twin girls was announced by a young Chinese scientist He Jiankui through one of four self-made promotional videos in English on YouTube (a website officially banned in China) on November 25. Three days later, at the Second […]
Rogue scientist: the human CRISPR experiment
By Jeanne Snelling and Mike King Chinese researcher, He Jiankui, claims to have implanted CRISPR-cas9 gene-edited embryos into potentially six women resulting in at least one successful pregnancy (of twins). Given the unconventional and inadequate way information has been released by He, and the fact that the research has not had thorough oversight, the facts […]