When evidence has only one arm: The ethical challenges of single arm trials

By Chiara Mannelli and Giuseppe Traversa Randomized controlled trials (RCTs) have long been regarded as the “gold standard” for testing new treatments. Yet in recent years, an increasing number of marketing authorizations – especially for cancer drugs – have been based on single arm trials (SATs). In these studies, all patients receive the experimental treatment, […]

Read More…

Not all persons are persons, yet some non-persons are persons: how one word hides two meanings

By Dr. Johnny Sakr Everyone thinks they know what a person is, right up until they try to define one. In their recent contribution to the Journal of Medical Ethics, Nancy Jecker and Caesar Atuire invite a richer and more humane account. Drawing on African philosophical traditions, they argue that personhood is not an isolated […]

Read More…

M3GAN 2.0: A case study in AI ethics and policy

By Ambria Williams, Lisa Kearns, and Kellie Owens This piece contains spoilers for the films “M3GAN” and “M3GAN 2.0”. Imagine a science fiction horror movie with an ethicist as the protagonist. As improbable as that seems, it’s the case in M3GAN 2.0, the sequel to the 2023 box-office hit M3GAN, in which an AI tech […]

Read More…

Confucian-inspired global bioethics

By Nancy S. Jecker and Roger Yat-Nork Chung. Bioethics faces challenges with respect to equity, diversity, and inclusion. As a group, we bioethicists are unrepresentative of the global population we increasingly serve. Leading bioethics scholars and institutions are situated mostly in the politically and economically dominant countries of the Global North. Within countries, bioethicists are […]

Read More…

Queering the genome: epigenome editing for biological lesbian motherhood

By Adrian Villalba. In the thrilling frontier of reproductive technologies, a ground-breaking approach aims to shake the foundations of conventional norms – it’s called epigenome editing. Imagine a world where same-sex couples can have genetically related children without the traditional genetic hurdles. Welcome to the era of “queering the genome”. This revolutionary technique bypasses the […]

Read More…

“Ethics first” reform for medical research in China: from reactive to proactive

By Jingyi Xu, Zhongxuan Liu, Jiayou Shi, Yue Wang. The 2018 CRISPR-babies incident, involving the controversial editing of human genomes, significantly impacted China’s approach to the ethics governance in medical research. The event underscored the need for a shift from a reactive, post hoc framework to a more proactive and anticipatory model. As a global […]

Read More…

Martha’s Rule and trust in healthcare: Beyond the ‘right’ to a second opinion

By Isabel Hanson. After the tragic death of thirteen-year-old Martha Mills in the UK, Martha’s mother Merope Mills said that she was told to “’Trust the doctors’… It turned out to be the worst advice I will receive in my whole life”. Martha had developed sepsis from an abdominal injury. Her mother knew that something […]

Read More…