Anti-neurofascin-155 antibodies: dissecting peripheral nerve abnormalities in CIDP

  In the June JNNP issue, Koike and colleagues have reported the morphological changes in sural nerve biopsies of patients with chronic inflammatory demyelinating polyneuropathy (CIDP) who have autoantibodies against paranodal structures. CIDP is an immune-mediated neuropathy that develops over 8 week, which manifests with progressive proximal and distal weakness and is associated with sensory […]

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Corpus callosum dysfunction in ALS: more than just connecting two sides

  In the May JNNP issue, Zhang and colleagues have published a study investigating the changes in structural and functional connectivity in patients with ALS. ALS is one of the most complex neurodegenerative diseases, which affects the motor system. It is characterized by concomitant degeneration of the upper and lower motor neurons, producing progressive weakness […]

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Prognostic factors in C9orf72 ALS: the battle of genders?

  The C9orf72 hexanucleotide repeat expansion has been defined as the main genetic factor in amyotrophic lateral sclerosis (ALS), particularly across the ALS-frontotemporal dementia (FTD) continuum. Clinically, the C9orf72-related ALS cases have several distinct features including an earlier age of onset, reduced survival, higher prevalence of bulbar onset and dementia, contributing to the broad clinical […]

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Immunomodulatory therapy modulates progression in advanced multiple sclerosis

  In the current issue of JNNP, Lizak and colleagues have published an interesting epidemiological study based on global multiple sclerosis (MS) database (MSBase), to evaluate prognostic factors in moderately advanced and advanced MS, specifically the impact of highly active immunomodulatory therapy. Using prospectively collected data from over 4000 patients with MS, the cohort was […]

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Doxycycline: bringing hope for early sporadic Creutzfeldt-Jakob disease patients

  In the current issue of JNNP, Varges and colleagues have published a randomized control trial (RCT) phase II comparing doxycycline versus placebo in early sporadic Creutzfeldt-Jakob disease (sCJD). CJD is a fatal and heterogeneous neurodegenerative disease caused by the misfolding and aggregation of prions. Clinically, CJD is characterized by rapidly progressive cognitive impairment associated […]

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How can we diagnose Susac syndrome?

  In the current issue of JNNP, Kleffner and colleagues have published the first diagnostic criteria for diagnosing Susac syndrome based on clinical and paraclinical findings. Susac syndrome is an uncommon disease characterized by the present of encephalopathy with or without focal neurological signs, branch retinal artery occlusion and neuro-sensorial hearing loss. Even though this […]

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Central autoimmune channelopathies: a link between Neurology and Psychiatry

  Since the recognition of antibodies against voltage – gated potassium channel (VGKC) and their pathogenic implication in central nervous system disorders (such as limbic encephalitis) in 2001, critical immunological and neurological advances have been achieved during the last 15 years. One of the main discoveries has been that these VGKC antibodies usually target proteins […]

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Melatonin an effective alternative for migraine prevention

  In the current issue of JNNP, Gonçalves and colleagues have published a randomized control trial (RCT) comparing melatonin, amitriptyline and placebo for migraine prevention. Migraine is a chronic neurological disease and has been ranked as the sixth disabling condition by World Health Organization (WHO). The goals of migraine prophylaxis are to reduce migraine attacks, […]

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Revealing the molecular fingerprint of oligodendroglial tumours

  In the current issue of JNNP, Iwadate and colleagues investigated the correlation between the changes in 11C-methionine positron emission tomography (PET) and the 1p/19q status in oligodendroglial tumours. Gliomas are the most common primary brain tumour in adults. Typically, based in the histological classification, gliomas have been classified into two major subgroups: (i) astrocytic […]

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Titin: a new piece in the puzzle of ALS

  In the current issue of JNNP, Watanabe and colleagues published a genome-wide association study (GWAS) in ALS to explore the effects of genetic variants in the disease course of sporadic ALS patients. ALS is an incurable neurodegenerative disease that affects the motor neurons in the cortex, brainstem, and spinal cord, typically resulting in death […]

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