The Neurology and Neuropsychiatry of COVID-19

  By Matt Butler, Cameron Watson, Mark Ellul, Tom Pollak, Benedict Michael and Tim Nicholson Evidence on the neurological and neuropsychiatric manifestations and complications of COVID-19 infections is emerging and this is likely to accelerate as the pandemic develops and clinical syndromes are detected, characterised and their mechanisms investigated. In this blog we will: Collate […]

Read More…

NEUROPSYCHIATRY: Past, Present and Future and into the 21st century

The 30th Anniversary Meeting of the British Neuropsychiatry Association and the Third British Symposium on the History of Neurology and Psychiatry Held at the Royal College of Surgeons, London. February 22nd 2017. Edward H Reynolds* and Timothy R Nicholson** *Department of Clinical Neurosciences, King’s College, London SE5 9PJ, UK. **Section of Cognitive Neuropsychiatry, Institute of […]

Read More…

Understanding the impact of psychosis in Huntington’s disease

In George Huntington’s original clinical monograph (1872), changes in mental state and behaviour were particularly noted in his description of patients with Huntington’s disease (HD) [1]. Despite the fact that such symptoms are frequently the most disabling, the illness phenotype beyond that of motor symptoms remains less narrated. In part, this is perhaps because non-motor […]

Read More…

Improving clinical trials in ALS

  The clinical trial design is extremely complex in neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS). The clinical and pathological heterogeneity of ALS has made therapeutic targets difficult to identify, increasing the variability in endpoints. Nowadays, the most effective interventions in ALS are multidisciplinary clinics and non-invasive ventilation, which can significantly improve quality of […]

Read More…

Jumping, Latah, and Miryachit: understanding neurobiological targets in Tourette Syndrome

In 1885, Gilles de la Tourette reported several patients with similar movement afflictions that were distinct from true chorea, which, in his case series, he named as the “jumping of Maine, latah of Malaysia, and miryachit of Siberia” [1].  Although a psychoanalytic aetiological view prevailed into the 20th Century, Tourette syndrome (TS) is now recognised […]

Read More…

Praxis of a new tool to sharpen neurodegenerative testing

  Clinicopathological correlation in dementia subtypes remains challenging, with similar clinical syndromes often caused by different pathologies. With the diagnosis of dementia relying primarily on clinical evaluation, this ambiguity clearly impacts clinical practice and has accelerated the search for biomarkers to help facilitate diagnosis and treatment. In this regard, apraxia profiling has recently gained momentum […]

Read More…

Sporadic Creutzfeldt-Jakob disease: beyond central nervous system dysfunction

  Sporadic Creutzfeldt-Jacob disease (sCJD) is a complex neurodegenerative disorder characterized by the accumulation of misfolded human prion protein (PrPSc). Classically, sCJD presents with neurological symptoms and signs of central nervous system (CNS) dysfunction, including cognitive impairment, cerebellar dysfunction, myoclonus, visual impairment and pyramidal signs, amongst others. Moreover, clinical diagnostic criteria requires the presence of […]

Read More…

Neurochemical changes in the ALS brain: further insights into disease heterogeneity

In a 1-year longitudinal study recently published in JNNP, ‘Neurochemical correlates of functional decline in amyotrophic lateral sclerosis’, ultra-high field 1H-MRS scans were used in 19 ALS patients by Cheong and colleagues to explore the relationship between neurochemical brain changes and functional decline. Specifically, the authors determined the regional levels of (i) N-acetylaspartate:myo-inositol (tNAA:mIns) from […]

Read More…

Primary lateral sclerosis and progressive muscular atrophy as a multidomain brain disorder

  From the diagnostic classification of amyotrophic lateral sclerosis (ALS) as defined in the El Escorial criteria, primary lateral sclerosis (PLS) and progressive muscular atrophy (PMA) have been considered as restrictive phenotypes, meaning that in PLS neurodegeneration is just restricted to the motor cortex and in PMA the loss of motor neurons occurs exclusively in […]

Read More…