Medication-overuse headache: finally, we have an intervention that works.

Headache. Common, painful, frustrating, exhausting- and that’s just what the neurologist feels when a headache patient walks in the room. The patients themselves are often at their wits end as headache, whatever the cause, is often functional incapacitating and can really ruin quality of life. Of all the headache types that are seen in neurology, […]

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Temozolomide reduces risk of seizures in low grade glioma!

Low grade gliomas are associated with a higher frequency of seizures.  While antieplipetic medications are utilized to reduced seizure frequency, in this issue of JNNP temozolomide was also associated with a a significant reduction in seizure frequency.  Perhaps temozolomide should be added to therapy of LGGs with intractable seizures.   Read more at http://jnnp.bmj.com/content/86/4/366.abstract   […]

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Spinal cord injury in multiple sclerosis: why is this important for MS clinical trials?

For patients with multiple sclerosis (MS), sustained long-term disability is a problem that elicits considerable concern. There is the impact on independence and the potential burden that it may lead to for caregivers. While treatments for MS seem to multiply by the year, established disability remains the one area that is still refractory to treatment. […]

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Confused about encephalopathy? Here’s something that may help.

Confusion. Agitation. Irritability. A wander around any emergency department or neurology ward will yield an abundance of observations that can fall under these categories and yet these are not all due to long waiting times or general hospital mayhem. All these symptoms are common presentations of neurological dysfunction and they are features of that syndrome […]

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Dementia in Parkinson’s disease: what can we do about it?

It has been around 200 years since James Parkinson first outlined the clinical features of the condition that would later bear his name. While his descriptions of Parkinson’s Disease (‘shaking palsy’) may have focussed largely around the motor manifestations of this condition, recent insights have provided strong evidence that non-motor manifestations contribute significantly to poor […]

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Infections and cancer: any link to brain tumours?

There have been numerous postulated links between the development of cancer following exposure to infectious organisms. In the case of the connection between human papilloma virus and cervical cancer, this association has led to ground-breaking treatments in the form of vaccination. A similar connection has been developed between hepatitis B and liver cancer. While many […]

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Neurodegeneration in MS: A clue to diability?

Corticla tarophy has been proposed as an imprtant pathophysiological mechanisms in disability development in progressive forms of multiple sclerosis.  A number of studies utilsing sophistcated MRI tehcniques have yielded such evidence.  In this issue of JNNP and elegant study demonstrated the importance of neurodegeneration at a pathological level, “reflected by a global reduction of neuronal […]

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Forbes Norris Award for editor of JNNP-Professor Matthew Kiernan

It gives me great pleasure to announce that Matthew Kiernan was awarded the highly prestigious Forbes Norris Award by the International ALS Alliance. The Forbes Norris Award, first presented in 1994, honours the memory of Dr. Forbes “Ted” Norris (1928 – 1993), a neurologist who dedicated his career to helping people with ALS/MND. The purpose […]

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