By Dominic Wilkinson @Neonatalethics and Michael Dunn @ethical_mikey Originally posted on PRACTICAL ETHICS In a high court case reported last week, a judge strongly criticised a London hospital’s clinical ethics committee (CEC). The case related to disputed treatment for a gravely ill nine-year old child. There had been a breakdown in the relationship between the […]
Category: Research Ethics
Why “human challenge” vaccine trials for COVID-19 are morally permissible, but only if we lock down, test, and contact-trace properly
By Ben Bramble We urgently need a vaccine for COVID-19, in order to fully end our lockdowns. The trouble is such vaccines usually take years to develop and test for efficacy and safety. Recently, a number of bioethicists have proposed “human challenge” vaccine trials to speed up the testing process. These involve volunteers receiving a […]
Finding a vaccine against the novel coronavirus: why challenge trials can be ethical even when a lot remains unknown
By Robert Steel, Lara Buchak, Nir Eyal Multiple authors believe that the development of coronavirus vaccines could be substantially accelerated through the use of challenge trials, in which participants are deliberately exposed to the virus. The tremendous loss of life and health and significant social and economic upheaval from ongoing worldwide pandemic make acceleration of […]
AI in healthcare – why start a conversation with the general public?
By Elizabeth Ford Imagine the future. Imagine you are 76 years old. You visit your doctor to have her examine your knee, which hurts since you fell over yesterday, tripping on your front step. After tapping some information into her computer, your doctor turns to you and says, “Would you like to discuss any concerns […]
CoViD-19: Time to rethink the RCT and consider more efficient and ethical approaches to clinical knowledge acquisition
By Michael Keane. A recent, much publicized, randomized controlled trial (RCT) demonstrated that the corticosteroid, dexamethasone, reduced mortality from CoViD-19. This was hailed as a practice-changing breakthrough. The authors announced that “RECOVERY is a large, pragmatic, randomized, controlled adaptive platform trial designed to provide rapid and robust assessment of the impact of readily available potential […]
Clamping down on unethical research: time for a moratorium on publishing Chinese transplant research
By Wendy A Rogers, Angela Ballantyne, Wendy C Higgins, Wendy Lipworth. Our paper in JME investigates the pros and cons of publishing and/or retracting unethical biomedical research. We focus on Chinese transplant research using organs procured from non-consenting executed prisoners. However, this is not the only topic currently raising questions about the justifiability of publishing […]
Can research participants break from the chain of traditional data sharing consent?
By Vasiliki Rahimzadeh In their recent article, Mann et al. propose to share biomedical research data more widely, securely and efficiently using blockchain technologies. Used to power cryptocurrencies such as Bitcoin, blockchain and the wider group of distributed ledger technologies provide new ways of exchanging data, including sensitive data such as health data, in that […]
How should the risks of infecting research participants with SARS-CoV-2 be assessed?
By Susan Bull, Euzebiusz Jamrozik, Ariella Binik, Michael Parker Vaccine development processes typically take ten to twenty years. The exceptional pace of COVID-19 vaccine research has resulted in early human trials being commenced with vaccine candidates. Calls have been made to conduct controlled human infection studies (CHIs), also known as challenge studies, with SARS-CoV-2 to […]
Ethical oversight during COVID-19: rewriting the norms of research ethics review?
By Anna Chiumento and Lucy Frith One consequence of physical distancing in response to the COVID-19 pandemic has been the rapid suspension or adaptation of ongoing research activity. This presents an opportunity for the research ethics community and researchers to promote ethical oversight that integrates the situated and informed judgement of researchers, rebalancing away from […]
Is Research Ethics Committee review of most clinical trials fundamentally broken?
By Mark Yarborough Imagine that you suffered from a fatal neurodegenerative disorder like Alzheimers or ALS, or that you had a serious chronic condition like hypertension or heart disease. Imagine further that you were asked to participate in a clinical trial related to your disease. Finally, imagine that the person recruiting you into the trial […]