BJSM Citation:
Walking or vitamin B for cognition in older adults with mild cognitive impairment? A randomized controlled trial.

Authors: Jannique G.Z. van Uffelen, Marijke J.M. Chinapaw, Willem van Mechelen, and Marijke Hopman-Rock
Links to:
ABSTRACT
ARTICLE

Although this study found that exercise improves some aspects of cognitive performance, it also confirmed a recent meta-analysis in concluding that that folic acid supplementation does not significantly benefit cognition. A recent article by our group suggested that much of the relationship between folate levels and cognition may be attributed to exercise because exercise is known to raise folate levels. The current article further reinforces the need for research investigating the interaction of exercise, folate, and cognitive performance.

Balk EM, Raman G, Tatsioni A, Chung M, Lau J, Rosenberg IH. Vitamin B6, B12, and folic acid supplementation and cognitive function: a systematic review of randomized trials. Arch Intern Med 2007; 167(1): 21-30.

Middleton LE, Kirkland SA, Maxwell CJ, Hogan DB, Rockwood K. Exercise: a potential contributing factor to the relationship between folate and dementia. J Am Geriatr Soc 2007; 55(7): 1095-8.