Hard science in difficult areas

It’s one of the delights of my professional clinical practice that (nearly) all the time, the diagnosis of a malignancy is hard & sound, reproducible, based on good data showing discrimination from other settings and with minimal interpersonal variation. Take a chunk of a particular renal tumour and show it to half a dozen paeds pathologists, […]

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Vague, unsure or imprecise?

Trials and tribulations we all have. The not-knowing of the future can create anxiety, distress and an unhealthy desire for chocolate. Some days, knowing what’s for tea can provide the only concrete grounding in an otherwise fluctuant universe. And along with that, the naming of things can sometimes be enlightening. So, for un-knowing, you could […]

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ADCE3 – Nothing seems right

 There are some times when it seems that no decision can be the right decision but doing nothing is as much as a decision as doing something. Admittedly, it’s rare you’re faced with shooting a killer in cold blood to prevent him murdering a not-so-innocent man. But sometimes the triadic nature of paediatric & adolescent […]

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Quality Improvement: Why it’s not turfing the RCT to the long grass

We’ve started to publish a fair few quality improvement reports in the Archives recently, aiming for 1200 words, 5 references and a readable SQUIRE-compliant paper that gets across the key messages about how a #QI project was undertaken. These aren’t trials, don’t have control arms, and may suffer from significant publication bias. (It’s not surprising to […]

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