Progressive skin fibrosis is associated with decline in lung function and worse survival in people with dcSSc

Worsening skin disease could be used as a marker of internal organ damage in people with diffuse cutaneous subtype of systemic sclerosis (dcSSc). Introduction Systemic sclerosis is a rare but serious disease of the connective tissues, characterised by thickening of skin and by triggering the immune system to attack itself (autoimmunity). This can cause hardening […]

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Immunosuppressant drugs may help in systemic sclerosis (dcSSc), but new treatments are needed

Immunosuppressants show some benefit in early dcSSc, but better treatments are still needed. INTRODUCTION Systemic sclerosis is a rare but serious disease of the connective tissues, where the tissue grows abnormally and triggers the immune system to attack itself (autoimmunity). This can cause hardening (fibrosis) and swelling of the skin, as well as joint pain, […]

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Skin sclerosis and digital ulcers develop quickly in people with early systemic sclerosis

People with early systemic sclerosis may quickly develop skin sclerosis and digital ulcers. INTRODUCTION Systemic sclerosis is a rare but serious disease of the connective tissues, where the tissue grows abnormally and triggers the immune system to attack itself (autoimmunity). This can cause hardening (fibrosis) and swelling of the skin, as well as joint pain, […]

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Ulcers on the fingers may predict disease worsening and survival in people with systemic sclerosis

People with digital ulcers early in the course of their systemic sclerosis may be more likely to suffer complications of the disease. INTRODUCTION Systemic sclerosis is a serious disease of the connective tissues, where the tissue grows abnormally and triggers the immune system to attack itself (autoimmunity). This can cause hardening (fibrosis) and swelling of […]

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Patients with systemic sclerosis have a high risk of bone fractures

Patients with systemic sclerosis may be more likely to develop osteoporosis and experience bone fractures. INTRODUCTION Systemic sclerosis is a serious disease of the connective tissues, where the tissue grows abnormally and triggers the immune system to attack itself (autoimmunity). This can cause hardening (fibrosis) and swelling of the skin, as well as joint pain, […]

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Rituximab may reverse fibrosis in patients with systemic sclerosis

Rituximab may offer a new treatment option in patients with systemic sclerosis. INTRODUCTION Systemic sclerosis is a serious disease of the connective tissues, where the tissue grows abnormally and triggers the immune system to attack itself (autoimmunity). This can cause hardening (fibrosis) and swelling of the skin, as well as joint pain, digestive problems and […]

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Lower-dose radiation scan for lung disease

People with systemic sclerosis may be able to have their lungs monitored for a complication of the condition using a scan that cuts their exposure to radiation. INTRODUCTION People with systemic sclerosis have an abnormal growth of connective tissue. This affects their skin, digestive tract, and other internal organs. It causes thickening of the skin and damage […]

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