In people with stable Lupus who are not taking intensive immunosuppressive drugs, live Herpes zoster vaccine works well. Introduction Systemic lupus erythematosus (often called Lupus or SLE) is an autoimmune disease. It typically starts in women between the ages of 15 and 45, but can start at a younger age. Lupus symptoms can vary from […]
Category: Drug treatment
Statin dose may affect development of osteoporosis
The diagnosis of osteoporosis in people treated with statins is dose dependent. Introduction Most people lose bone density as a normal part of ageing. Osteoporosis is a condition where a person’s bone density is reduced, making their bones fragile and more likely to fracture (break). Hip, wrist and spine (back) fractures are the most common […]
TNF inhibitors can be used after JAK inhibitors
People with an insufficient response to adalimumab or upadacitinib achieved better responses after switching to the alternative. Introduction Rheumatoid arthritis is a chronic inflammatory disease that affects a person’s joints, causing pain and disability. Rheumatoid arthritis affects people of all ages, and is more common in women than men. Treatments for rheumatoid arthritis aim to […]
Shortened antibiotic use for successfully drained septic arthritis
For septic arthritis in the hand or wrist that has been drained, 2 weeks of antibiotics works as well as 4 weeks. Introduction Septic arthritis is a bacterial infection in a joint. It may develop quickly, and causes inflammation, swelling and pain. Septic arthritis affects both adults and children. These kinds of infections can affect […]
Switch to baricitinib delivers results with no need for washout
Switching from adalimumab to baricitinib delivers improvements in disease control, physical function and pain within 12 weeks, without additional side effects. Introduction Rheumatoid arthritis is a chronic inflammatory disease that affects a person’s joints, causing pain and disability. It can also affect internal organs. Rheumatoid arthritis is more common in older people and it affects […]
Unmet needs remain in rheumatology
Defining unmet needs that can stimulate research into understanding diseases better and lead to the development of new targeted therapies, disease prevention and ultimately cure remains a priority in rheumatology. Introduction Rheumatology is a field of medicine that studies and treats people with various conditions that affect their joints, bones, tendons, ligaments and muscles – […]
New medicines for Lupus should also be tested in children with Lupus
Innovative new trial designs mean it will be possible to test new medicines in rare diseases such as childhood Lupus. Introduction Systemic lupus erythematosus (often called Lupus or SLE) is an autoimmune disease. It typically affects women between the ages of 15 and 45, but can start in younger children. There are many things that […]
Risk of some types of serious bacterial infection are higher with tocilizumab than TNFi
Serious bacterial infection, skin and soft tissue infection, and diverticulitis are more common with tocilizumab than TNFi, but there is no overall difference in the rates of serious infection including bacterial, viral or opportunistic infection. Introduction Rheumatoid arthritis is a chronic inflammatory disease that affects a person’s joints, causing pain and disability. It can also […]
Risk of side effects increased in people from certain racial or ethnic backgrounds
Allopurinol should be used with caution in people with Black, Asian, or Native Hawaiian/Pacific Islander heritage. Introduction Gout is a very common condition. It is caused by deposits of crystals of a substance called uric acid (also known as urate) in the joints, which leads to inflammation. Periods of time when you have gout symptoms […]
Tailored treatment may be a possibility for AAV in people with GPA or MPA
AAV relapse rates did not significantly differ between individually tailored and fixed schedule rituximab regimens. Introduction Granulomatosis is a medical term for a disease where granulomas – or clusters of certain cell types – are formed. This can happen in immune or inflammatory diseases. People can have with granulomatosis with polyangiitis (also known as Wegener’s […]
