JAKi associated with a higher malignancy compared with TNFi but not placebo or methotrexate; cancers were rare events in all comparisons. Introduction Janus kinase inhibitors (shortened to JAKi) are a group of medicines that are prescribed for autoimmune inflammatory conditions such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease. They have also been studied in […]
Category: Autoimmune disease
Updated: Vaccination of children with AIIRD
This is the lay version of the EULAR recommendations for vaccination of children with an autoimmune rheumatic disease. The original publication can be downloaded from the EULAR website: www.eular.org. Introduction EULAR gives advice to doctors, nurses, and patients about the best way to treat and manage diseases. Health professionals and patients worked together to develop […]
Proportion of severe COVID cases decreasing in people with rheumatic disease
The proportion of people with a rheumatic disease getting severe COVID has diminished since early in the pandemic INTRODUCTION COVID-19 (often referred to as COVID) is the disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). It was declared a pandemic by the World Health Organization in March 2020. The infections caused by the initial […]
Remission and LDA are relevant targets in the management of SLE
The first study examining the independent impact of remission and LDA definitions on damage accrual. INTRODUCTION Systemic lupus erythematosus (often called Lupus or SLE) is an autoimmune disease. It typically starts in women between the ages of 15 and 45. Lupus symptoms can vary from patient to patient. People with Lupus are often very tired, […]
COVID boosters in AIIRD
Immunogenicity induced by two and three doses of the BNT162b2 mRNA vaccine in patients with autoimmune inflammatory rheumatic diseases and immunocompetent controls: a longitudinal multicentre study. INTRODUCTION COVID-19 is the disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). It was declared a pandemic by the World Health Organization in March 2020. Vaccination against SARS-CoV-2 […]
Inflammation correlates with PROs in early RA
In the early phases inflammatory variables directly correlate with the PGA across different disease activity states INTRODUCTION Rheumatoid arthritis is a chronic inflammatory disease that affects a person’s joints, and may cause pain and disability. Rheumatoid arthritis can affect people of all ages, but it most often starts between the ages of 40 and 60. […]
New QIs help assess and improve care in Lupus
Quality indicators can help clinics to implement the EULAR recommendations in everyday care INTRODUCTION Systemic lupus erythematosus (often called Lupus or SLE) is an autoimmune disease. It typically starts in women between the ages of 15 and 45. Lupus symptoms can vary from patient to patient. People with Lupus are often very tired, have joint […]
Warfarin users more likely to need joint replacement
Warfarin is associated with greater risk of osteoarthritis than other types of anticoagulant. INTRODUCTION Osteoarthritis is a common condition that makes a person’s joints painful. Some people also experience stiffness when seated for a prolonged period of time. Osteoarthritis is caused by breakdown of the cartilage and changes in the bones as well as other […]
Increased COVID-19 risk in autoimmune disease, but not more severe
People with autoimmune disease have an increased risk of getting infected with COVID-19, especially if they use steroid medicines. However, the risk of severe outcomes of COVID-19 such as hospitalisation or death is not increased. INTRODUCTION COVID-19 is the disease caused by a new type of coronavirus called severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). It […]
People can regain remission after relapse with rituximab plus steroids
Rituximab plus steroids are useful for putting people back into remission after a relapse of their AAV. INTRODUCTION ANCA-associated vasculitis (shortened to AAV), is a rare group of diseases of the immune system. These diseases are linked to a type of autoantibody called ANCA. An antibody is a protein that the normal healthy immune system […]
