The renin-angiotensin-aldosterone system (RAAS) appears to have an important role in the development of atherosclerosis. The Aliskiren Quantitative Atherosclerosis Regression Intravascular Ultrasound Study (AQUARIUS) sought to determine if direct renin inhibition with aliskiren slows atherosclerosis progression in patients with already controlled blood pressure. […]
Tag: IVUS
SATURN shows plaque statin benefit
Statins have revolutionized the treatment of cardiovascular disease and have repeatedly demonstrated their ability to reduce adverse cardiovascular outcomes. However despite tantalizing data from some trials suggesting statins may even be capable of causing disease regression, few studies have formally assessed the comparative ability of competing drugs to achieve this. […]
IVUS reveals importance of non-culprit lesions
A substantial proportion of individuals who present with an acute coronary syndrome will go on to have repeat events, however the lesion related factors driving these repeat events remain poorly understood. Data from retrospective and pathological studies have suggested that many lesions that lead to clinical events are thin-walled lipid-rich lesions that are angiographically mild […]