Both clinical and experimental evidence have suggested an anti-arrhythmic effect of long-chain n-3 polyunsaturated fatty acids (n-3-PUFAs) in fish oil. However, the effect of n-3-PUFAs on atrial arrhythmias such as postoperative atrial fibrillation (AF) remain uncertain. The Omega-3 Fatty Acids for Prevention of Post-operative Atrial Fibrillation (OPERA) trial was designed to test whether perioperative n-3-PUFA […]
Tag: omega-3
Fish oils fail to prevent cardiovascular events in diabetics
The use of fish derived n-3 fatty acids following myocardial infarction has been shown to be beneficial in preventing further cardiovascular events and reducing mortality, particularly from sudden cardiac death. However the effects of these drugs in preventing cardiovascular events in high risk patients with (or at risk for) type 2 diabetes mellitus, but who […]
Omega-3 fatty acid levels and congestive heart failure
Long-chain omega-3 polyunsaturated fatty acids have previously been associated with a reduced risk of coronary death, however their effect on other cardiovascular outcomes – such as congestive heart failure (CHF) – are less well established. As CHF is one of the leading causes of hospitalisations, novel targets for its prevention are a priority. […]
Omega-3 meta-analysis shows mortality benefit
Data from the GISSI-Prevenzione study[Lancet 1999;354:447-55] suggested that omega-3 fatty acids may have the ability to reduce death from cardiovascular causes, mainly through a reduction in sudden cardiac death (SCD). However, subsequent studies among patients with implantable cardiac defibrillators (ICD) failed to demonstrate any reduction in device therapy with supplemental fish oils, possibly due to […]