Despite large reductions in blood pressure seen in early studies of renal denervation, the SYMPLICITY HTN-3 randomized trial failed to show a reduction in systolic blood pressure with renal denervation when compared to medical therapy alone. As a result, interest in renal denervation as a treatment for resistant hypertension has waned. In the DENERHTN trial, […]
Tag: hypertension
Renal denervation misses the mark in resistant hypertension
The prospect of percutaneous renal-artery denervation to treat hypertension has been widely heralded in response to pilot studies that demonstrated marked reductions in blood pressure after renal denervation. Despite the rapid adoption of catheter-based renal artery denervation, data from large scale randomised controlled trials remains absent. A total of 535 patients with severe resistant hypertension […]
Blood pressure control, not the specific medication regimen, is what matters
The Blood Pressure Lowering Treatment Trialists’ Collaboration examined primary data from 23 trials as well as summary data from an additional 3 trials to define the cardiovascular effects of lowering blood pressure in people with and without chronic kidney disease. This study included randomized trials of drugs to lower blood pressure that were compared to […]
Low awareness, treatment and control of hypertension across the globe
Hypertension is associated with 7.6 million deaths worldwide and is the leading modifiable risk factor for cardiovascular disease (CVD). However, global studies of hypertension prevalence, awareness, treatment, and control are lacking. The PURE (Prospective Urban Rural Epidemiology) study involves urban and rural communities in 3 high-income, 10 middle-income, and 4 low-income countries. CVD risk factors […]
Catheter-based treatment of hypertension shows promise
Renal sympathetic efferent and afferent nerves are crucial for the initiation and maintenance of systemic hypertension, and as such renal sympathetic denervation is a potential therapeutic target for hypertension.Krum et al. describe the development of a novel, percutanoeus, catheter-based approach to renal sympathetic denervation.The lumen of the main renal artery is cannulated and the surrounding […]