Richard Lehman’s weekly review of medical journals

NEJM  8-15 Dec 2016  Vol 375 Geographical variation in trials This review article on geographical subgroup variation is a master class in how to think about and analyze randomised controlled trials. […]

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NEJM  1 Dec 2016  Vol 375 Can genes prove how drugs work? Medicine is the application of neat science to a messy world. We love it when it works simply: […]

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NEJM  24 Nov 2016  Vol 375 AAA in UK & USA It grieves me to say it, but there are certain things that American medicine does better than British medicine. […]

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NEJM  17 Nov 2016  Vol 375 Diabetes kills in Mexico City “Overall, between 35 and 74 years of age, the excess risk of death associated with diabetes accounted for approximately […]

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NEJM  10 Nov 2016  Vol 375 Reinventing connected medicine A 1300 word Viewpoint article can hardly do justice to a theme as grand as “Meaning and the Nature of Physicians’ […]

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NEJM  3 Nov 2016  Vol 375 Tolerating uncertainty “At once it struck me what quality went to form a Man of Achievement . . . when a man is capable […]

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Oxygen for moderate COPD This week saw the official launch of the UK Academy of Medical Royal Colleges “Choosing Wisely” campaign, which was so successful that its website crashed. It […]

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NEJM  20 Oct 2016  Vol 375 Fainting and pulmonary emboli   O Padua, sidus praeclarum,          O Padua, brilliant star, hocce nisa fulgido                          luminous model virtutum regula morum                   of virtues and […]

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NEJM  13 Oct 2016  Vol 375 Outcomes and choices This week’s print NEJM contains mostly papers I’ve already commented on—notably, Gilbert Welch’s important study of mammography and breast cancer outcomes […]

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NEJM 6 Oct 2016 Vol 375 MI: better care counts in long term Forty years ago, it was generally safer to stay at home with a myocardial infarction. Archie Cochrane demonstrated […]

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