JAMA 21 Mar 2007

Reduction of Atherothrombosis for Continued Health (REACH) could be a description of what we spend half our time doing in primary care, but it is also the name of a big 44-country register of people with known atherosclerosis or with 3 or more risk factors. And yes, the event rate matches the number of atheromatous sites and the number of risk factors, and continues in linear fashion with time. And these patients are all receiving “contemporary risk-reduction therapies