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Welcome to the BMJ Open blog. BMJ Open is a new open access, online general medical journal, dedicated to publishing medical research from all disciplines and therapeutic areas.

Publication has begun - see the latest articles here and find out more about the journal here.

We will be updating the blog with news about the journal, events and matters of interest in the open access and publishing world, and anything else that catches our eye.

Using the SPIRIT statement to improve trial protocols

18 Jan, 13 | by Richard Sands, Managing Editor


We have updated our instructions for authors to show that we now encourage the use of the SPIRIT statement.

SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) is ‘an international initiative that aims to improve the quality of clinical trial protocols by defining an evidence-based set of items to address in a protocol’. Its creation was funded by four Canadian health research institutions.

The full statement has been published in the Annals of Internal Medicine, and the explanation and elaboration in the BMJ. BMJ Open’s editor-in-chief, Dr Trish Groves, is a member of the SPIRIT group.

BMJ Open published 17 protocols in 2011 and 79 in 2012, though not all were for interventional trials. We require ethics approval and registration in an ICMJE-approved registry for trial protocols, and encourage registration of systematic review protocols in PROSPERO, led by BMJ Open editorial board member Prof Lesley Stewart.

Publishing protocols provides a valuable service by allowing researchers to publicise ongoing work and hopefully facilitating cooperation and reducing duplicated efforts. By making the intended methods fully available the chances of a study’s replication may be enhanced. Protocol publication should also ensure that any changes to methods adopted during a trial are reported as such in results papers.

As the SPIRIT authors write, ‘High quality protocols facilitate proper conduct, reporting, and external review of clinical trials.’ We will be encouraging authors to use SPIRIT to help meet these goals.

2012 year in review

11 Jan, 13 | by Richard Sands, Managing Editor

 

2012 was a hugely successful year for BMJ Open. We published four times as many papers as in 2011. Credit for this must go, first and foremost, to the hundreds of reviewers who have given their time to assess manuscripts. We are also grateful that so many authors have chosen to publish with us.

2013 has begun promisingly with the news that Thomson Reuters are now tracking BMJ Open for inclusion in the Web of Science. Indexing begins soon.

We received over 1200 submissions in 2012 and published 654 papers, making a total so far of over 800 papers published since launch. Seventy-nine 2012 papers were protocols, helping promote the transparency in research that comes from publishing research plans in advance of the work being carried out.

Authors from 74 countries submitted their work to us and we accepted papers from 49 countries. Twenty-six studies now have associated datasets in the Dryad repository. The majority of these submissions came straight to BMJ Open. However, authors whose work is turned down by another BMJ Group journal can transfer it to BMJ Open, along with any peer reviewers’ reports, and many have chosen to take advantage of this. We now also have a panel of dedicated statistical reviewers to help expedite review of those papers where a statistical assessment is required.

So we are confident that our proposition – open peer review, open data, open access – is popular with authors, many of whom have published more than once in BMJ Open. Many reviewers, after first-hand experience of the review process from that side, have subsequently submitted papers too.

In September 2012 we launched the BMJ Open Editions – six channels to showcase BMJ Open papers from the key areas of dermatology, HIV/Aids, infectious diseases, neurology, obstetrics & gynaecology and oncology

As our scholarly profile grows, so does our public profile. BMJ Open papers have featured regularly in the news during 2012, and we will be posting about that separately. Of particular note, though, was a paper published in February by Kripke, Langer & Kline, on mortality and cancer risks associated with specific currently popular hypnotics. This paper received almost 50 000 full-text and PDF downloads in 2012 and was the most downloaded paper of the year. All articles have usage statistics available online.

This paper received widespread media coverage and some robust online responses. We would love to see more of this kind of debate in 2013. We welcome e-letters or less formal comment and we always encourage authors to respond. Many of the comments we have received have been perceptive and passionate and one or two have led to us publishing corrections and even to the posting of further data in Dryad – post-publication peer review in action.

2012 was a watershed year for open access, and while it is strongly supported by high-profile grant-awarding institutions, many researchers do not have this backing and cannot pay article-processing charges (APCs). They may be working in countries with severely limited resources, students/early-stage researchers without access to institutional funds, unaffiliated or simply working without a grant.

Despite relying on APCs to run the journal, we still welcome all research and in 2012 waived the publishing fee for over 100 papers. This amounts to over £120 000 of APCs waived. By subsequently submitting papers, many of our reviewers were able to take advantage of the reviewer discount we offer as well.  

Thank you again to our reviewers for their hard work, our authors for placing their trust in BMJ Open, and our editorial board for their support. We look forward to continuing to work with you and many new colleagues in 2013.

Most read articles in December

9 Jan, 13 | by BMJ Group

The most read article in December was Bellis and colleagues’ study of mortality amongst rock and pop stars, which also received a great deal of press attention. The second most read was Rajavashisth et al‘s study of diabetes prevalence amongst marijuana users which was originally published way back in February 2012. Bergman et al‘s newly published paper on Vitamin D3 supplementation and frequent respiratory tract infections was also highly read.

 

Rank Author(s) Title
1 Bellis et al

Dying to be famous: retrospective cohort study of rock and pop star mortality and its association with adverse childhood experiences

2 Rajavashisth et al

Decreased prevalence of diabetes in marijuana users: cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) III

3 Bergman et al

Vitamin D3 supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study

4 Kern et al Does low-dose acetylsalicylic acid prevent cognitive decline in women with high cardiovascular risk? A 5-year follow-up of a non-demented population-based cohort of Swedish elderly women
5 Kripke et al Hypnotics’ association with mortality or cancer: a matched cohort study
6 Tikkinen et al

What is a disease? Perspectives of the public, health professionals and legislators

7 Arroll and Howard A preliminary prospective study of
nutritional, psychological and combined
therapies for myalgic encephalomyelitis/
chronic fatigue syndrome (ME/CFS) in a
private care setting
8 Swinglehurst et al

Computer templates in chronic disease management: ethnographic case study in general practice

9 Lee et al UK stroke incidence, mortality and cardiovascular risk management 1999–2008: time-trend analysis from the General Practice Research Database
10 Teder et al

Family-based behavioural intervention programme for obese children: a feasibility study

 

Most read figures are based on pdf downloads and full text views. Abstract views are excluded.

Most read articles in November

11 Dec, 12 | by jghosh

The most read article in November was Arroll and Howard’s newly published prospective study on therapeutic approaches to myalgic encephalomyelitis/chronic fatigue syndrome. The second most read was also a new study, by Liao and colleagues, on the content and quality of information in online advertisements for female genital cosmetic surgery.

Rank Author(s) Title
1 Arroll and Howard A preliminary prospective study of
nutritional, psychological and combined
therapies for myalgic encephalomyelitis/
chronic fatigue syndrome (ME/CFS) in a
private care setting
2 Liao et al An analysis of the content and clinical implications of online advertisements for female genital cosmetic surgery
3 Kern et al Does low-dose acetylsalicylic acid prevent cognitive decline in women with high cardiovascular risk? A 5-year follow-up of a non-demented population-based cohort of Swedish elderly women
4 Kripke et al Hypnotics’ association with mortality or cancer: a matched cohort study
5 Harris et al The essential elements of health impact assessment and healthy public policy: a qualitative study of practitioner perspectives
6 Cottrell et al Using simple telehealth in primary care to reduce blood pressure: a service evaluation
7 Lee et al UK stroke incidence, mortality and cardiovascular risk management 1999–2008: time-trend analysis from the General Practice Research Database
8 Beresniak et al Relationships between black tea consumption and key health indicators in the world: an ecological study
9 Patterson et al Consumption of takeaway and fast food in a deprived inner London Borough: are they associated with childhood obesity?
10 Townsend and Pitchford Baby knows best? The impact of weaning style on food preferences and body mass index in early childhood in a case–controlled sample

Most read figures are based on pdf downloads and full text views. Abstract views are excluded.

Most read articles in October

13 Nov, 12 | by BMJ Group

The most read article in October was Laursen and colleagues’ newly published study of the effects of exercise volume and intensity upon the risk of metabolic syndrome. For the second month running, Ekström et al‘s cohort study of the effectiveness of metformin was second most read and Kripke et al‘s study of hypnotics and mortality remains the third most-read article some nine months after its publication.

Rank Author(s) Title
1 Laursen et al Intensity versus duration of physical activity: implications for the metabolic syndrome. A prospective cohort study
2 Ekström et al Effectiveness and safety of metformin in 51 675 patients with type 2 diabetes and different levels of renal function: a cohort study from the Swedish National Diabetes Register
3 Kripke et al Hypnotics’ association with mortality or cancer: a matched cohort study
4 Kern et al Does low-dose acetylsalicylic acid prevent cognitive decline in women with high cardiovascular risk? A 5-year follow-up of a non-demented population-based cohort of Swedish elderly women
5 Mak Coronary and mortality risk of novel oral antithrombotic agents: a meta-analysis of large randomised trials
6 Townsend and Pitchford Baby knows best? The impact of weaning style on food preferences and body mass index in early childhood in a case–controlled sample
7 Katzmarzyk and Lee Sedentary behaviour and life expectancy in the USA: a cause-deleted life table analysis
8 Lee et al UK stroke incidence, mortality and cardiovascular risk management 1999–2008: time-trend analysis from the General Practice Research Database
9 Henderson et al Shame! Self-stigmatisation as an obstacle to sick doctors returning to work: a qualitative study
10 Patterson et al Consumption of takeaway and fast food in a deprived inner London Borough: are they associated with childhood obesity?

Most read figures are based on pdf downloads and full text views. Abstract views are excluded.

New: BMJ Open Editions

22 Oct, 12 | by Richard Sands, Managing Editor

Since launch in 2011, BMJ Open has published more than 600 open access original research articles and protocols on a wide variety of subjects in medicine and healthcare. An increasing number of these papers have linked datasets in the Dryad repository.

We are hugely grateful to the authors, peer reviewers and funders who have made all of this possible.

Now, we are delighted to announce the launch of the BMJ Open Editions. We’ve developed these editions to showcase and aid the discoverability of BMJ Open’s specialist research, initially from oncology, neurology, obstetrics and gynaecology, infectious diseases, HIV/AIDS and dermatology.

Our new editions demonstrate our commitment to these particular areas of research but BMJ Open remains committed to publishing research from all areas of medicine and healthcare.

High impact studies published to date include a technique to pick up outbreaks of hospital acquired infections more quickly from Oxford University; the potential link between sleeping pills and cancer from California’s Scripps Clinic; and unique research on the wellbeing and quality of life of people with locked-in syndrome.

BMJ Open is a natural home for research funded by organisations and institutions such as the US National Institutes of Health, the UK Medical Research Council and the Wellcome Trust, because it allows authors to comply with their mandates to make all research openly accessible. In addition, we deposit all articles in PubMed Central without embargo and ensure that authors retain copyright for their work.

We hope you will consider BMJ Open when publishing your next paper and we look forward to receiving your manuscript.

Most reads articles in September

11 Oct, 12 | by BMJ Group

The most read article in September was Aston and colleagues’ modelling study of meat consumption and greenhouse gas emissions in the UK. Ekström et al‘s cohort study of the effectiveness of metformin was the second most read and Taylor et al‘s study of the impact of substance misuse remains highly read in third place.

Click on the titles to read the articles in full.

Rank Author(s) Title
1 Aston et al Impact of a reduced red and processed meat dietary pattern on disease risks and greenhouse gas emissions in the UK: a modelling study
2 Ekström et al Effectiveness and safety of metformin in 51 675 patients with type 2 diabetes and different levels of renal function: a cohort study from the Swedish National Diabetes Register
3 Taylor et al Quantifying the RR of harm to self and others from substance misuse: results from a survey of clinical experts across Scotland
4 Wallace et al Barriers to the uptake of evidence from systematic reviews and meta-analyses: a systematic review of decision makers’ perceptions
5 Dahlen et al Rates of obstetric intervention among low-risk women giving birth in private and public hospitals in NSW: a population-based descriptive study
6 Kripke et al Hypnotics’ association with mortality or cancer: a matched cohort study
7 Katzmarzyk and Lee Sedentary behaviour and life expectancy in the USA: a cause-deleted life table analysis
8 Rautio et al Do statins interfere with lifestyle intervention in the prevention of diabetes in primary healthcare? One-year follow-up of the FIN-D2D project
9 Nagai et al Impact of walking on life expectancy and lifetime medical expenditure: the Ohsaki Cohort Study
10 Heneghan et al  The evidence underpinning sports performance products: a systematic assessment

Most read figures are based on pdf downloads and full text views. Abstract views are excluded.

Most read articles in August

18 Sep, 12 | by BMJ Group

The most read article in August was Taylor and colleagues’ analysis of the relative risk of harm associated with substance misuse, which was originally published at the end of July.

Click on the titles to read the articles in full.

Rank Author(s) Title
1 Taylor et al

Quantifying the RR of harm to self and others from substance misuse: results from a survey of clinical experts across Scotland

2 Heneghan et al The evidence underpinning sports performance products: a systematic assessment
3 Katzmarzyk and Lee Sedentary behaviour and life expectancy in the USA: a cause-deleted life table analysis
4 Kripke et al Hypnotics’ association with mortality or cancer: a matched cohort study
5 Ayres and Bond A chemical analysis examining the pharmacology of novel psychoactive substances freely available over the internet and their impact on public (ill)health. Legal highs or illegal highs?
6 Townsend and Pitchford Baby knows best? The impact of weaning style on food preferences and body mass index in early childhood in a case–controlled sample
7 Dexter et al Strategies to increase influenza vaccination rates: outcomes of a nationwide cross-sectional survey of UK general practice
8 Collin et al Equity of access to specialist chronic fatigue syndrome (CFS/ME) services in England (2008–2010): a national survey and cross-sectional study
9 Hoddinott et al A serial qualitative interview study of infant feeding experiences: idealism meets realism
10 Neyt et al A cost-utility analysis of transcatheter aortic valve implantation in Belgium: focusing on a well-defined and identifiable population

Most read figures are based on pdf downloads and full text views. Abstract views are excluded.

Most read articles in July

9 Aug, 12 | by BMJ Group

The most read article in July was Heneghan and colleagues’ analysis of sports performance products, which received widespread press attention and was also accompanied by a BBC Panorama special. The second most read paper, Katzmarzyk and Lee’s life table analysis of life expectancy and sedentary behaviour, also received large amounts of press coverage both in Europe and the US. Kripke et al‘s study of hypnotics and mortality remains highly read, and is still in the top three some five months after its publication.

Click on the titles to read the articles in full.

Rank Author(s) Title
1 Heneghan et al

The evidence underpinning sports performance products: a systematic assessment

2 Katzmarzyk and Lee

Sedentary behaviour and life expectancy in the USA: a cause-deleted life table analysis

3 Kripke et al Hypnotics’ association with mortality or cancer: a matched cohort study
4 Townsend and Pitchford Baby knows best? The impact of weaning style on food preferences and body mass index in early childhood in a case–controlled sample
5 Hoddinott et al

A serial qualitative interview study of infant feeding experiences: idealism meets realism

6 Jorgensen et al

 

Human semen quality in the new millennium: a prospective cross-sectional population-based study of 4867 men

7 Lee et al UK stroke incidence, mortality and cardiovascular risk management 1999–2008: time-trend analysis from the General Practice Research Database
8 Patterson et al Consumption of takeaway and fast food in a deprived inner London Borough: are they associated with childhood obesity?
9 Wheelock et al

Views of policymakers, healthcare workers and NGOs on HIV pre-exposure prophylaxis (PrEP): a multinational qualitative study

10 Ekstrom et al

Effectiveness and safety of metformin in 51 675 patients with type 2 diabetes and different levels of renal function: a cohort study from the Swedish National Diabetes Register

BMJ Open in the news

11 Jul, 12 | by Richard Sands, Managing Editor

 

BMJ Open research has made the news again. The paper by Peter T Katzmarzyk (Pennington Biomedical Research Center) and I-Min Lee (Harvard) on the impact of sitting and television viewing on life expectancy in the USA has received widespread coverage, from the BBC in the UK, through numerous US news outlets, and as far as the New Zealand Herald. At the time of writing it has also received over 5500 views.

To give visitors to the site an idea of where BMJ Open papers are being discussed our homepage now includes a news feed – click on the ‘In the news’ tab on our homepage and you will discover links to sites covering the latest BMJ Open research.