While the measurement and management of cholesterol forms an integral part of cardiovascular risk management, it has been suggested that risk assessment could be improved by the assessment of various additional lipid-related markers either to supplement or replace traditional cholesterol measurements. The aim of this paper was to determine whether cardiovascular risk prediction could be […]
Tag: phospholipase A2
Novel enzyme inhibitor shows promise for atherosclerosis inhibition
Secretory phospholipase A2 (sPLA2) enzymes are involved in the production of bioactive lipids that contribute to atherosclerosis. They are highly expressed in human and mouse atherosclerosis, and different groups of the enzyme contribute differently to atherosclerosis. A-002 (1-H-indole-3-glyoxamide, veraslpadib methyl, Anthera pharmaceuticals, CA) is a novel inhibitor of sPLA2 in humand with specificity towards sPLA2-I1A, […]