Why standardisation threatens reproducibility

BMJ Open Science encourages a number of initiatives to help the work that we publish be reproducible such as pre-submission manuscript checking, encouraging reporting guidelines, and asking authors to report the strengths and limitations of their experiments. However, reproducibility should also be considered at the study design stage. A recent study1 based on extensive preclinical data […]

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Registered Reports at BMJ Open Science: Making preclinical research match-fit for translation

By Chris Chambers, @chrisdc77 In 2015 the UK Academy Medical of Sciences published a landmark report documenting the current state of reproducibility in preclinical and biomedical research. The analysis makes for sobering reading. Preclinical science is littered with small, biased studies, underspecified procedures, and poor statistical methods, driven by perverse career incentives that prioritise quantity […]

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Setting the Agenda: ‘Who are we answering to’?

  By Frank Miedema, PhD @MiedemaF ‏ The Health Council of the Netherlands recently concluded that the dominant use of academic metrics had, from the perspective of the public, shaped  the research agenda of the eight University Medical Centers in an undesirable way. Fields of research that are badly needed because of disease, economic and social burden […]

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The QUEST to transform translational biomedical research has begun

  The QUEST center at the Berlin Institute of Health celebrated its opening with an international symposium. A diverse cast of speakers outlined current challenges in the scientific process and a possible roadmap to transform biomedical research. Trish Groves (Director of academic outreach at BMJ and Editor-in-Chief of BMJ Open) spoke about the meaning of […]

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Lessons learned from the MVA85A vaccine: our approach to addressing these issues

  By Emily Sena @drEmilySena This week’s The BMJ includes a collection of articles on preclinical animal studies! As editor-in-chief of BMJ’s first ‘science’ journal it’s exciting to see the conversation about the validity of preclinical animal studies and the manner with which they inform the development of new treatments for patients feature in our big […]

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