By Sloka Iyengar A basic scientist in the clinic After nine years studying epilepsy, and despite deep immersion into the scientific literature and scientific methodology of epilepsy, I had yet to see a person experiencing seizures. This all changed on my first day as a clinical researcher, where I met Kevin – a boy […]
Drug Discovery and Preclinical Drug Development – Have Animal Studies Really Failed?
By Thomas Steckler and Malcolm Macleod The ethics of the use of animals in research continue to be a matter for discussion, with a recent op-ed in the Journal of Translational Medicine arguing – on the grounds that non-human animals are quite different from “human animals” – that animal models can no longer be considered helpful in the development […]
“Lost in the Maze? Navigating Evidence and Ethics in Translational Neuroscience”: Herrenhausen Conference, Hannover, Germany 2018
By Sarah McCann ‘It is a veritable desert as far as favourable outcomes in neurological research are concerned’ –Jonathan Kimmelman, bioethicist The reasons behind our failure to translate preclinical efficacy to clinical benefit, and the ethical challenges associated with early phase clinical trials of these treatments were dissected and debated at Herrenhausen Palace in February. […]