The Moral Desirability of Early Fatherhood

Guest Post by Kevin Smith

It is well known that the risk of disorders resulting from chromosomal abnormalities, such as Down’s syndrome, correlates with advancing maternal age.  Less widely known is the correlation between the age of fathers and an increased risk of a range of disorders in their resultant offspring, the most prominent of which are neuropsychiatric conditions including schizophrenia and autism.  This is the paternal age effect, the importance of which has recently become clear through a growing body of molecular genetic and epidemiological data.

The paternal age effect results from new mutations occurring in the stem cells from which sperm cells are derived, resulting in an accumulating mutational burden as the male ages.  Genetic abnormalities resulting from these paternal mutations are usually subtle at the molecular level (involving as little as a single nucleotide change), highly heterogeneous, and do not usually result in detectable foetal abnormalities.  Accordingly, the opportunity for prenatal detection of such cases is very limited.  (By contrast, the genetic abnormalities associated with maternal aging typically involve substantive chromosomal aberrations, comprise a relatively restricted range of commonly occurring forms, and frequently produce marked foetal defects; these features ensure that routine screening and testing reveals the majority of such cases prior to birth, permitting termination of affected foetuses.)  Additionally, and again in contrast to genetic aberrations associated with maternal age, paternal de novo mutations are transmitted through successive generations of males, with a concomitant intergenerational accumulation of genetic abnormalities.  Moreover, at least in Western societies, the average age of fatherhood is increasing markedly, a situation that will increase the burden of these mutations.  It follows that the age of potential fathers is of significant ethical importance.

My paper explores the ethical aspects of paternal age, in respect of both individual procreative decisions and societal responsibilities.  I argue inter alia that, somewhat contrary to the commonplace disapproval of young parents, early fatherhood is ethically desirable.  The most immediate practical means to achieve a reduction in paternal de novo mutations and associated genetic disorders would be the promotion of sperm banking amongst young males.

Read the full paper here.

  • D.A.A. Verkuyl

    One aspect
    of the older father/mother discussion is not mentioned. If women have their
    children young, then 4, with increasing life-expectancy in future perhaps 5,
    generations are alive simultaneously instead of 3. This would make at least a
    billion difference in human prevalence. A potential problem much greater than warned
    for in this paper. Nigeria had in 1960 45 million inhabitants, currently 180,
    projections 900 million in 2100. Presently 30% of under-five’s malnourished. If
    people there started their family at a much older age, it could perhaps prevent
    an even worse situation as in the north now, like the Congo wars more than 5
    million deaths, and of course thousands dying in the Mediterranean? It could moreover
    also have climate consequences. It is much easier to sustainably maintain
    everybody’s right to have children as the generations are well spaced (sorry
    you have great grandchildren but will never meet them). Starting young with
    having children is having your cake and eat it.

    Of course, it would be much more rational to have much
    higher vasectomy incidences at a much
    younger (semen still young and fresh) age and store and label the relevant semen conscientiously, but
    attempts to do this haven’t flourished