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Of Tusks and Tuskegee: A Problem in Research Ethics

1 Mar, 12 | by Iain Brassington

Xtaldave, by his own admission, has the horn.  Well, if you’re being accurate about it, he has the tusk.  But what’s important is that he has a whopping great piece of ivory to play with.

Dave works in the labs here in Manchester, doing clever things with chemicals and science and crystalography and that sort of thing.  The ivory has been confiscated by customs; it found its way into his lab because the dentine in a great big tooth is a useful medium on which to carry out research that may generate significant benefits.  In his words, the tusk is

an acceptable substitute for human bone in the sorts of assays that our lab does to test the effect of various substances on cells called Osteoclasts that are responsible for bone resorption (basically bone destruction).  During growth and development of the skeleton, bone is formed (by Osteoblasts) and broken down (by Osteoclasts) – it is thought that the bone disease Osteoporosis is caused by an imbalance of bone formation and destruction – i.e. too much Osteoclast activity.

If we can find a therapeutic agent that inhibits Osteoclast activity, we might be able to halt or slow the progression of Osteoporosis.  The upshot of all this is that our lab has obtained a section of Elephant horn that has been confiscated by the UKBA.  We will recycle this and use the dentine in our bone resorption assays.

Why’s this of interest here?  Well, the ivory trade is (a) illegal, and (b) deeply morally problematic.  The fact that it’s illegal means that the UK Border Agency confiscates ivory as it’s imported into the country in most cases.  (There are situations in which importation is legal, but they’re rare, and needn’t concern us here.)  And this confiscation means that the Agency ends up with a load of ivory on its hands.

One option might be to sell it; but that’s ruled out by the same considerations that make importation illegal to begin with.  Another is simply do destroy the lot.  A third is to allow labs like Dave’s to make use of it.  This is where the moral claims come in.  It would be, he says, immoral (as well as legally problematic) to sell the ivory, and

if someone has already killed the elephant and removed the Ivory, better that we use it to further medical research and perhaps save or improve some lives, than turn it into a bauble that sits on a shelf gathering dust.

Or, to put it another way: that the elephant has been killed is bad; but we can at least salvage something from the moral wreckage.

Is this correct?  Well, the structure of the argument seems to follow quite closely that which is sometimes presented in relation to the use of – for example – data derived from the morally repugnant experiments of the past.  If there is, in Stan Godlovich’s words, “demonstrably important and beneficial information gathered methodically through means completely unacceptable to us”, what should we do with it?

A famous example of such research is the Dachau hypothermia experiments, of which a good overview is given by Berger in the New England Journal of Medicine in 1990.  Berger concludes that, actually, the results generated are unreliable, and so “attempts to use the data from the Dachau experiments have been puzzling”.  But there’s an important question lingering in the background: suppose the results had actually been scientifically credible, and could have led to a better understanding of hypothermia – and thence to better treatments: would it be OK to use them?

The “salvage from the wreckage” argument might apply here.  Granted that the murdered people cannot be revived, we should concentrate on the living and making the world as good a place as possible.  Some might even say that it would be wrong not to use the data, for a couple of reasons: first, there’s an obligation to benefit humanity that might be discharged by helping develop new treatments; second, ignoring the data would simply compound the waste that generating them represented.

On the other hand, we might worry that making use of the data indicates a willingness to see the murdered people simply as a source of information – which was precisely the attitude that allowed the procedures to happen in the first place.  A more Kantian line might be that willing the end implies willing the means necessary thereto; and if the only way to do the new science is to rely on old murderous science, then the new science involves tacit endorsement of the old.

Though I find it hard to deny that the salvage argument has power, my own inclination is that using such data would be problematic.  I’ve argued in a couple of places that arguments for the obligatoriness of scientific research fail (see here and here); and part the research I’m doing at the moment involves raising sceptical doubts about whether a duty to pursue scientific research could ever be established.  If there’s no duty to research, though, it becomes supererogatory.  And if it’s supererogatory, then the salvage argument looks weaker.  After all, if noone is wronged by the absence of new research, then the imperative to do it diminishes; and granted that certain sources of data are contaminated, then “dirty hands” worries might turn out to carry the moral weight.  Sometimes, it’s possible that we ought simply to walk away from some opportunities to benefit humanity.  Our duty is not to harm; we don’t have a duty to make things better, and certainly not if other important considerations are at stake.

Similar thoughts might well turn out to apply in respect of using elephant tusk.  Of course, some will insist that there’s a world of difference between poached elephants and what went on in Dachau, or Manchuria, or Tuskegee.  In one sense, there might be.  From the point of view of moral argumentation, though, there isn’t such a gulf.  In both cases we’re dealing with actions that we can take to be straightforwardly wrong, but which generate things that turn out to be useful, and which could be used in pursuit of something admirable.  (I’m assuming, arguendo, that the science is sound.)  The structure of the problem seems to me to be very similar indeed.

Does this mean that Dave shouldn’t be doing his experiments on elephant tusk?  I don’t think that anything in this post establishes that.  But the salvage argument in favour of making use of morally contaminated resources in science isn’t – I don’t think – always all that compelling.  And if it isn’t compelling in this case, then letting the ivory sit on a shelf – even if it means hindering osteoporosis research – might turn out to have something to be said for it.

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  • Nicholas Barton

    Surely the attitude that allowed the Dachau procedures to happen in the first place was seeing *then yet-to-be-murdered* people simply as a source of information, which is an important distinction. I'm a lot more inclined to care about people who haven't been murdered than those who already have.

  • Possibly. But they'd've been in much less peril to begin with had they not been seen as the sort of thing – and the word “thing”, rather than “person” or even “creature” – that could be treated as scientific raw material in the first place.

  • Darryl Gunson

    Both the Ivory and the Dachau cases do seem to invite the 'salvage from the wreckage' argument. Your first objection to applying it to the Dachau case seems to be that we will see dead people as means rather than ends. Thus violating Kantian principles. I don't believe it myself, but being as you raise this, surely the difference is that the (dead) people are (were) the kinds of beings that the categorical imperative applies to ie. rational autonomous (in the Kantian way). Elephants on the other hand, although reputed to have good memories, don't seem to be clever enough!

    So there is a difference and we can if we like have soem qualms about the one case whilst happily endorsing the use of the ivory for good ends.

  • Not necessarily.

    What matters here (at least for a Kantian) is that, if some action that we agree to be wrong is necessary to achieve a given end, then we have to abandon the end. Of course, there's a higher-order argument to be had subsequently about whether killing elephants really is wrong, and why (and here modern Kantians might differ from Kant). If it is wrong, it doesn't have to be for the same reason that killing people is wrong – all that matters for the sake of this first-order argument is that we think that it is wrong for some reason.

    Another quick point: I'd disagree with your use of the CI. The CI applies to the agent, not to the thing acted-upon: that is, it says that we have certain duties, therefore some things are protected, not that some things are protected, therefore we have corresponding dutues. It would still be binding in an otherwise empty universe. If elephants turn out to be persons, then the CI tells us that we have direct duties just as we would in respect of human persons. If they aren't persons, though, we'd still have certain indirect duties in respect of them, and duties to self that'd be mediated by them – as per the discussion at the end of the Doctrine of Virtue 6:429-6:443. Either way, killing elephants might turn out to be something that we can't do out of respect for the CI; either way, we'd be back to the means/ ends argument.

  • Darryl Gunson

    I'm still not convinced Iain. As to your first point, even if we accept the Kantian view about abandoning ends that require evil means, it is not the case that the ivory is necessary for the research into osteoparosis. It may be sufficient, but not necessary. So, it looks as though your point doesn't apply.

    As to your other point, I agree that the CI applies to the agent. So the qiestion is: are you (as agent) treating moral beings as means rather than as ends? In the case of elephants the answer is no because they do not have the direct moral status required to be included within the intended scope of the CI.

  • Ok – but if the ivory isn't necessary, doesn't that make the salvage argument weaker still?

    I think that the second point still stands: if it's true that elephants don't have “inherent” moral worth, it doesn't follow that there's no duties that bind us in relation to them – and here I think that a thoroughgoing Kantian could reassert the arguments about indirect duties and duties to self.

  • Darryl Gunson

    a.I don't think so.
    b. I never said we don't have any (indirect)duties to elephants. But if we do, I think it is highly implausible that one of them is the  duty-not-to-regard-dead-elephants-in-an-instrumental-fashion.
    And even if we did, using the ivory for research does not mean that we would necessarily be violating that duty.

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