CELLWAVE: bone marrow cells improve ventricular function

In patients with chronic postinfarction heart failure, bone marrow-derived mononuclear cell (BMC) therapy has demonstrated mixed results to date.  One possible reason for this is that cell retention by the heart is more difficult in the stable setting in comparison to therapies given following acute myocardial infarction, however a recent discovery found that extracorporeal application […]

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SCIPIO: Stem cells improve ischaemic cardiomyopathy

Ischaemic heart disease remains the leading cause of heart failure in the Western World, and its prevalence continues to rise. Despite marked advances in the treatment of heart failure, heart muscle death remains irreversible.  However, over the last decade the concept of the heart as a terminally differentiated organ has been refuted, and this has […]

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Differentiation of resident stem cell population improves cardiac function

The quest to regenerate functional myocardium from stem cells following myocardial infarction has garnered a great deal of media attention and has become something of a holy grail in cardiovascular medicine.  Despite the basic science of stem cells still being at an early stage, the first human trials have already been conducted – but the […]

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