Novel risk markers – CT looks strong

The primary prevention of cardiovascular disease involves classifying individuals according to their global cardiovascular risk. However, those at intermediate risk represent a particular challenge; while some may require aggressive treatment, others may be best managed by lifestyle measures alone. Biomarkers that have shown promise in improving risk discrimination include carotid intima-media thickness (CIMT), coronary artery […]

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Fish oils fail to prevent cardiovascular events in diabetics

The use of fish derived n-3 fatty acids following myocardial infarction has been shown to be beneficial in preventing further cardiovascular events and reducing mortality, particularly from sudden cardiac death. However the effects of these drugs in preventing cardiovascular events in high risk patients with (or at risk for) type 2 diabetes mellitus, but who […]

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Chronic NSAID use increases mortality from cardiovascular disease

Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective and extensively used pain-killers, particularly in the treatment of chronic musculoskeletal problems.  However, doubts about their safety in patients with coronary disease have surfaced, particularly since the NSAID-like COX1 inhibitor, rofecoxib, was withdrawn from the market after a demonstrated  increase in cardiovascular events.  Despite these concerns, compelling data on […]

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Lipid metabolism by gut flora influences cardiovascular disease

Although the relationship between cholesterol, triglycerides, and cardiovascular disease is well established, little is known about the role of the third major class of lipids – phospholipids.  In this regard, the intestinal microflora play a crucial role in that they digest and absorb many crucial nutrients, including lipids.  Therefore in this study the authors attempted […]

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Plastics additive linked to cardiovascular disease

Bisphenol A (BPA) is the base chemical used to make several plastic containers, cans and dental sealants.  Evidence from animal studies has suggested several potential biological effects of BPA, including estrogenic activity, liver damage, thyroid hormone dysfunction, and obesity-promotion. […]

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