Another nail in the preverbial coffin for CCSVI theory?

Chronic cerebrospinal venous insufficiency (CCSVI) was proposed as a potential pathogenic mechanism in MS.  While pathological data to support such a theory were elusive, a world-wide craze was sett-off, mostly amongst patients, some vascular physicians and some (minority) of neurologist.  It seamed appealing that a simple vascular problem was responsible for MS, but alas subsequent […]

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The Sound of Music

My sister is doing a degree in music.  I listen, fascinated, to her stories; music school isn’t like med school.  Their days begin around noon, fellow students sport wild hair colours and outfits (tutus anyone?), and the last exam she sat was held upstairs in the local pub.   Image credit: http://www.keepcalm-o-matic.co.uk/p/study-your-exam-and-have-a-beer–1/   Most people enjoy […]

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Sleepy heads

It’s 1.30am, Friday morning.  I’m struggling to keep awake on the first night shift of the year.  One down (well half of it anyway), six more to go.  I’m a light sleeper at the best of times, however, after a busy med reg night shift, it’s a different story.  I’ve slept through our smoke alarm […]

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The New Wonder Drug

I’m currently working as a junior doctor in a subacute hospital, on the Neurology Ward. Our in-patients come in for symptom management, and sometimes end of life care. Conditions include motor neuron disease, Huntington’s disease, multiple sclerosis, and the Parkinson Plus ‘three ugly sisters’ (although I’ve only seen MSA & PSP in my time here). […]

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Feeling hot hot hot!

Happy new year! I’m typing this blog on the living room floor, under the air con.  The south-east of Australia is in the middle of a heat wave; my home town had four consecutive days with temperatures over 40 degrees Celsius (that’s over 104 degrees Fahrenheit for those playing in other parts of the world). […]

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Below the surface

  Dr Susanna Park reviews the recent JNNP hits:   Condensed in this word cloud is the year 2013……as seen in the Journal of Neurology, Neurosurgery & Psychiatry. From the abstracts of original research papers and reviews from the Journal in 2013, the 150 most commonly used words are depicted graphically, with the most frequently […]

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Non-contiguous propagation of ALS: River of hyperexcitability?

The site of disease onset in ALS remains enigmatic, and resolution of this quandary could shed light of ALS pathogenesis and may be of therapeutic significance. Previous studies suggested a contiguous spread of disease, implying a role for local (spinal) factors in ALS pathogenesis. In contrast, Sekiguchi and colleagues report non-contiguous spread, a well observed […]

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