Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers

In March 2014 the International Gastric Cancer Linkage Consortium, a group of worldwide experts in the field of Hereditary Diffuse Gastric Cancer, held a consensus meeting in the Radboudumc in Nijmegen, The Netherlands. During this three-day meeting, the current evidence and world-wide experience for managing individuals with a family history of diffuse type gastric cancer was discussed. New criteria for CDH1 mutation testing, as well as updated endoscopy screening and surveillance protocols are described in the revised guideline. Additionally, the treatment of carriers of germline CDH1 mutations are extensively discussed including prophylactic surgery as well as nutritional and psychological needs. (By Dr. Ingrid Vogelaar, http://jmg.bmj.com/content/52/6/361 )

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The IGCLC group

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