Standard therapy for the treatment of acute pulmonary embolism (PE) consists of regimes involving anticoagulation therapy alone. Thrombolytic therapy (TT) may provide a mechanism for more rapid thrombus resolution and improvement in pulmonary blood flow and may therefore offer benefit among certain patient groups, such as those presenting with features of cardiopulmonary compromise. However, previous […]
Tag: thrombolysis
No additional benefit from thrombolysis during out-of-hospital cardiac arrest
Myocardial infarction and pulmonary embolism account for approximately 70% of out of hospital cardiac arrests. Cardiac arrest itself activates systemic coagulation hence thrombolytic therapy delivered during cardiopulmonary resuscitation can dissolve intravascular blood clots and has beneficial effects on microcirculatory reperfusion, improving survival and neurological recovery. […]
Thrombolysis in stroke: minutes mean mind
The current thrombolysis guidelines for acute ischaemic stroke recommend thrombolysis with alteplase initiated within 3 hours of symptom onset. This was following the landmark findings of the 1995 National Institute of Neurological Disorders and Stroke (NINDS) study group. The ECAS III trial (European Cooperative Acute Stroke Study), a multi-centre, randomised, placebo controlled phase 3 trial […]