Ischaemia reperfusion injury (IR) is characterised by abnormal increases in intracellular calcium during myocardial reperfusion that lead to cardiomyocyte death. In addition, IR is accompanied by an increase in the expression of microRNAs (miRNAs) such as miR-214, which has previously been identified as a sensitive marker of cardiac stress. […]
Tag: microRNA
p53, microRNAs, and myocardial infarction
MicroRNAs (miRNA) are short nucleotide chains that act as inhibitors of gene expression. Specifically, miR-499 is a cardiac-abundant microRNA that can prevent cardiomyocyte apoptosis by targeting calcineurin-mediated activation of Drp1, an enzyme that normally results in fission of mitochondrial tubules into fragments. miR-499 may therefore have a key role to play following myocardial infarction, as […]