Two trials in the Journal of the American Medical Association (JAMA) address the impact of bone marrow-derived cell therapy on safety and surrogate endpoints in patients with ventricular dysfunction due to ischaemic heart disease. […]
Tag: bone marrow cell
FOCUS-CCTRN: Autologous bone marrow cells fail to improve heart failure
Autologous stem/progenitor cells have been investigated for several years as a novel therapy for patients with advanced ischaemic heart disease, particularly those with ongoing angina or heart failure. In particular, for patients with ischaemic cardiomyopathy, autologous bone marrow mononuclear cells (BMCs) have been shown to be safe and possibly effective. However, none of the trials […]
Intramyocardial bone marrow cell injection improves myocardial perfusion
Animal studies have suggested that bone marrow cell injection can improve myocardial perfusion and improve ventricular function in chronic ischaemia, but the two randomized trials performed to date in humans have yielded conflicting results. […]