The CEA Second-Look Trial: a randomised controlled trial of carcinoembryonic antigen prompted reoperation for recurrent colorectal cancer

A trial that remained unpublished for 20 years casts doubt on the survival benefit of repeat (“second look”) surgery for bowel cancer. The trial is published in BMJ Open today. It is the first to be restored under the restoring invisible and abandoned trials (RIAT) initiative that allows third parties to publish previously abandoned studies […]

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Painkillers linked to heightened irregular heartbeat risk in older adults

Current and recent use of painkillers/anti-inflammatories may be linked to a heightened risk of an irregular heartbeat (atrial fibrillation) among older adults, finds a large population study published in BMJ Open. Atrial fibrillation has itself been linked to stroke, heart failure, and reduced life expectancy, while previously published research has linked the use of non-steroidal […]

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Girls born small or underweight twice as likely to be infertile in adulthood

Girls born unexpectedly small or underweight seem to be twice as likely to have fertility problems in adulthood as those of normal size at birth, suggests research published in BMJ Open. Medical advances mean that more underweight and very small babies will survive into adulthood, which might therefore increase the prevalence of fertility problems, say […]

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Tobacco industry claims “plain” packs won’t work based on weak evidence

Most studies lack policy relevance; and relevant research lacks key indicators of quality, including peer review A critical evaluation of the volume, relevance and quality of evidence submitted by the tobacco industry to oppose standardised packaging of tobacco products doi:10.1136/bmjopen-2013-003757 Tobacco companies lack strong, relevant evidence to support their claims that standardised (plain) packaging of […]

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Clinical Commissioning Groups in England serve too many masters

Accountability regime much more complex than in previous system; potentially competing agendas Clinical Commissioning Groups, the new family doctor-led bodies responsible for commissioning the largest chunk of healthcare in England, are accountable to too many masters with potentially competing agendas, concludes research published in BMJ Open. Clinical Commissioning Groups, or CCGs for short, are membership […]

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UK women scientists have fewer studies funded, and are given less money, than men

Women scientists specialising in infectious disease research have fewer studies funded than men, and receive less funding across most topic areas in the specialty than their male peers, finds a study published in BMJ Open. These gender discrepancies have remained broadly unchanged for more than a decade, the findings show. Attempts should be made to explore […]

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