Evidence Watch: should ‘rooming in’ be the norm?

  Evidence suggests rooming-in should be the norm in hospitals but what factors will limit uptake  Carl Heneghan Here’s what we selected this week: Daily vs intermittent antituberculosis therapy for pulmonary tuberculosis in patients with HIV a randomized clinical trial. JAMA Internal Medicine, 178(4), 485–493. Bottom line:  HIV-positive patients with pulmonary TB receiving antiretroviral therapy, do […]

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Frailty’s impact on mortality

  A systematic review concludes that frailty is a predictor of mortality, but does it aid decision making in practice? Carl Heneghan A recent systematic review included 18 cohort studies including 65,048 participants. The results suggested that higher Frailty index was significantly associated with higher mortality risk. For every 0.01 increase in the index the […]

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Adverse effects of antidepressants in younger adults

  SSRIs might have higher rates of fracture than tricyclic antidepressants but lower mortality and adverse reactions. Carl Heneghan Antidepressants are commonly prescribed. Yet, in those under 65, there is scant evidence on the risks associated with their use. A recent publication in BMC  looked at these risks in a cohort of 20 to 64-year […]

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