The EBM Verdict tracker is updated monthly to select the research evidence that can matter to clinical practice: EBM Verdict articles are published in BMJ EBM. EBM Verdict Evidence that helps you come to a definitive conclusion and can be implemented into clinical practice. Introducing the EBM Verdict: research evidence relevant to clinical practice […]
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Evidence Watch: should ‘rooming in’ be the norm?
Evidence suggests rooming-in should be the norm in hospitals but what factors will limit uptake Carl Heneghan Here’s what we selected this week: Daily vs intermittent antituberculosis therapy for pulmonary tuberculosis in patients with HIV a randomized clinical trial. JAMA Internal Medicine, 178(4), 485–493. Bottom line: HIV-positive patients with pulmonary TB receiving antiretroviral therapy, do […]
Frailty’s impact on mortality
A systematic review concludes that frailty is a predictor of mortality, but does it aid decision making in practice? Carl Heneghan A recent systematic review included 18 cohort studies including 65,048 participants. The results suggested that higher Frailty index was significantly associated with higher mortality risk. For every 0.01 increase in the index the […]
Adverse effects of antidepressants in younger adults
SSRIs might have higher rates of fracture than tricyclic antidepressants but lower mortality and adverse reactions. Carl Heneghan Antidepressants are commonly prescribed. Yet, in those under 65, there is scant evidence on the risks associated with their use. A recent publication in BMC looked at these risks in a cohort of 20 to 64-year […]
Centrally-acting drugs for obesity cause more harm than good
Centrally acting medicines increase the chance of losing at least 5% of body weight, but their use increases the risks of serious of harms Igho Onakpoya Are the benefits and harms of currently available centrally-acting weight loss drugs (medicines that act on the brain) different from those withdrawn from the market at the time of […]