Question: How to diagnose and treat pyelonephritis

In children suspected of having a UTI, what clinical and radiological features diagnoses pylonephritis, and what mode of antibiotic treatment is necessary to produce clinical improvement and avoid chronic renal impairment? With the publication of the NICE guidance in the UK on the management of UTI in childhood, many paediatricians have been spurred to review […]

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GnRH analogues to prevent ovarian failure?

Should gonadotropin releasing hormone analogue be administered to prevent premature ovarian failure in young women with systemic lupus erythematosus on cyclophosphamide therapy? A 15 year old girl with acute renal failure was found to have class IV systemic lupus erythematosus (SLE) nephritis on renal biopsy. A decision was taken to start her on the routine […]

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