Expanding the antibody spectrum of limbic encephalitis!

Limbic encephalitis (LE) mat have an underlying autoimmune etiologiy.  over the last decade numerous antibodies have emerged as potenital causative agents, and the antibodies have been directed against external epitopes of specific receptors.  In an upcoming issue of JNNP, Onugoren and colleagues reaffirm the association between GABAB and AMPR receptor antibodies and LE.  Importantly neoplastic […]

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Cholinesterase inhibitors in Parkinsons disease?

Cholinesterase inhibitors (ChIs) improve cholinergic transmission and thereby may lead to improved cognitive function in PD, although the risk of side-effects such as falls may be potentially increased.  In an upcoming issue of JNNP (On line first)  Pagano and colleagues conducted a meta-analysis to further assess these issues.  The results show a clear improvement of […]

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IVIg versus methylprednisone in CIDP: The treatment dilemmas!

The long-term treatment of CIDP is a vexing one often mired in lack of data from randomized controlled trials.  The ICE study suggested that a maintenance IVIg dose of 1g/kg every 3 weeks is associated with good therapeutic outcome.  Subsequent studies have suggested that steroids may lead to remission in a greater proportion of patients, […]

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NMO versus MS: The debate of discriminators continues!

Differentiating NMO from MS may be a difficult task.  Yet the distinction is crucial as treatment and prognosis vary.  In an upcoming issue of JNNP (On line first) an elegant review discusses potential clinical, CSF and radiological discriminators between NMO, NMO spectrum disorder and MS. Read more at: J Neurol Neurosurg Psychiatry doi:10.1136/jnnp-2014-308984 Multiple sclerosis […]

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Attention junior doctors: assessing delirium in hospital, it’s time to pay attention.

If you take a wander through your local hospital emergency department, you will generally not find any similarity to what you see on TV. It will not look like an episode of ‘ER’, with ambulances pulling up at breakneck speed and doctors yelling instructions in an attempt to save a life. Generally, the atmosphere is […]

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