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Weight gain, smoking cessation, and cardiovascular risk

18 Mar, 13 | by Alistair Lindsay

It is known that smoking cessation substantially reduces the risk of cardiovascular disease (CVD), but does any subsequent weight gain attenuate the benefits of quitting smoking? ┬áThe goal of this study was to answer this question in adults with and without diabetes. ┬áSpecifically, the authors tested the hypothesis that quitting smoking decreases CVD risk compared with continuing smoking, regardless of any associated weight gain. more…

Varenicline: no link with cardiovascular events found in meta-analysis

18 May, 12 | by Alistair Lindsay

Varenicline (Champix) is a partial agonist to nicotine receptors, and is approved for smoking cessation therapy. However, the FDA has raised concern about a possible increase in the incidence of cardiovascular events of patients taking the drug in randomised trials. In this meta-analysis, Prochaska et al. looked at 22 randomised controlled trials of current tobacco users and compared cardiovascular events in those given varenicline compared to those given placebo. Cardiovascular adverse events were defined if they occurred during drug treatment or within 30 days of discontinuation. All the trials included in the analysis were double blind and placebo controlled, and two included participants with active cardiovascular disease, while eleven enrolled patients with a history of cardiovascular disease. Rates of cardiovascular serious adverse events were 0.63% in the varenicline groups and 0.47% in the placebo groups. The summary estimate for the risk difference (0.27%, P=0.15) was not significant either clinically or statistically. more…

Smoking cessation provides rapid vascular benefit

18 Jul, 08 | by Alistair Lindsay

A causal relationship between smoking and cardiovascular death is well established. But, for those patients who successfully stop smoking, are the detrimental effects fully reversible? And if so, how quickly do the benefits become apparent? more…

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