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Fish Oils Don’t Decrease Post-Op AF

25 Nov, 12 | by Alistair Lindsay

Both clinical and experimental evidence have suggested an anti-arrhythmic effect of long-chain n-3 polyunsaturated fatty acids (n-3-PUFAs) in fish oil.  However, the effect of n-3-PUFAs on atrial arrhythmias such as postoperative atrial fibrillation (AF) remain uncertain.  The Omega-3 Fatty Acids for Prevention of Post-operative Atrial Fibrillation (OPERA) trial was designed to test whether perioperative n-3-PUFA supplementation could reduce postoperative AF. more…

Fish oils fail to prevent cardiovascular events in diabetics

19 Sep, 12 | by Alistair Lindsay

The use of fish derived n-3 fatty acids following myocardial infarction has been shown to be beneficial in preventing further cardiovascular events and reducing mortality, particularly from sudden cardiac death. However the effects of these drugs in preventing cardiovascular events in high risk patients with (or at risk for) type 2 diabetes mellitus, but who are otherwise stable, are unknown. In the double-blind, multi-centre ORIGIN study 12,536 patients who had impaired fasting glucose, impaired glucose tolerance, or diabetes, were randomised in a 2-by-2 factorial design to receive either a 1-g capsule of n-3 fatty acids or placebo daily (with the other arm of the study randomising to receive either insulin glargine or standard care). Mean age of participants was 64 and 59% had had a previous cardiovascular event at baseline. The primary outcome was death from cardiovascular causes. After a median follow up of 6.2 years there was no significant difference between the n-3 fatty acids and placebo arms as regards the primary outcome (574 patients [9.1%] vs. 581 patients [9.3%];HR, 0.98; 95% CI, 0.87 to 1.10; P=0.72). The use of n-3 fatty acids also had no significant effect on the rates of major vascular events (P=0.81), death from any cause (P=0.63), or death from arrhythmia (P=0.26). Similarly, the use of insulin glargine in the other arm of the study failed to improve cardiovascular outcomes. more…

Omega-3 fatty acid levels and congestive heart failure

7 Aug, 11 | by Alistair Lindsay

Long-chain omega-3 polyunsaturated fatty acids have previously been associated with a reduced risk of coronary death, however their effect on other cardiovascular outcomes – such as congestive heart failure (CHF) – are less well established.  As CHF is one of the leading causes of hospitalisations, novel targets for its prevention are a priority. more…

Omega-3 meta-analysis shows mortality benefit

14 Apr, 09 | by Alistair Lindsay

Data from the GISSI-Prevenzione study[Lancet 1999;354:447-55] suggested that omega-3 fatty acids may have the ability to reduce death from cardiovascular causes, mainly through a reduction in sudden cardiac death (SCD). However, subsequent studies among patients with implantable cardiac defibrillators (ICD) failed to demonstrate any reduction in device therapy with supplemental fish oils, possibly due to methodological limitations such as small sample size, poor patient adherence and high loss to follow up. Furthermore, previous systematic reviews of fish oil therapy have been inconclusive but have not included some of the most recent data, such as the JELIS trial [Lancet 2007;369:1090-8]. more…

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