p53, microRNAs, and myocardial infarction

MicroRNAs (miRNA) are short nucleotide chains that act as inhibitors of gene expression. ┬áSpecifically, miR-499 is a cardiac-abundant microRNA that can prevent cardiomyocyte apoptosis by targeting calcineurin-mediated activation of Drp1, an enzyme that normally results in fission of mitochondrial tubules into fragments. ┬ámiR-499 may therefore have a key role to play following myocardial infarction, as […]

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