Top 10 Most Read: Antidepressant use during pregnancy, medical graduates’ preparedness for practice and E-therapies for stress, anxiety and depression

January sees 5 new entries into the top 10 most read articles. At number 4 is a cohort study by Anick Bérard and colleagues investigating the association between first-trimester exposure to antidepressants and the risk of major congenital malformations in 18,487 depressed/anxious women from Quebec, Canada. Results indicate that antidepressants increase the risk of a wide range of organ-specific malformations. At number 6 is a systematic review and meta-analysis by Tea Reljic and colleagues suggesting that, in terminally ill patients, active treatment targeted at underlying disease does not have a demonstrable impact on overall survival compared to palliative care.

Also making its way into the top ten is a rapid review of the literature examining the preparedness of UK graduates for practice as junior doctors. Whilst the review indicates that junior doctors are well prepared in a number of different areas of practice, some problem areas are identified including safe and legal prescribing, multidisciplinary team-working, handovers, breaking bad news to patients, learning needs and reflective practice.

Other new entries this month include a systematic review of life expectancy among individuals with non-cancer chronic disease and a survey of web and smartphone apps used and recommended for stress, anxiety or depression by the National Health Service in England. Fenton et al.’s systematic review of dietary acid load, alkaline water and cancer moves up four positions to become January’s most read article.


Rank Author(s) Title
1 Fenton et al. Systematic review of the association between dietary acid load, alkaline water and cancer
2 Ravnskov et al. Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review
3 Boulton et al. How much sugar is hidden in drinks marketed to children? A survey of fruit juices, juice drinks and smoothies
4 Bérard et al. Antidepressant use during pregnancy and the risk of major congenital malformations in a cohort of depressed pregnant women: an updated analysis of the Quebec Pregnancy Cohort
5 Murdoch  et al. Selling falsehoods? A cross-sectional study of Canadian naturopathy, homeopathy, chiropractic and acupuncture clinic website claims relating to allergy and asthma
6 Reljic et al. Treatment targeted at underlying disease versus palliative care in terminally ill patients: a systematic review
7 Hole et al. How long do patients with chronic disease expect to live? A systematic review of the literature
8 Bennion et al. E-therapies in England for stress, anxiety or depression: what is being used in the NHS? A survey of mental health services
9 Monrouxe et al. How prepared are UK medical graduates for practice? A rapid review of the literature 2009–2014
10 Steele et al. Ultra-processed foods and added sugars in the US diet: evidence from a nationally representative cross-sectional study

Most read figures are based on pdf downloads and full text views. Abstract views are excluded.