You don't need to be signed in to read BMJ Blogs, but you can register here to receive updates about other BMJ products and services via our site.

Unanswered Question: Is LDH a good predictor of malignancy in children?

30 Jul, 07 | by BMJ

A four-year old girl presents to the accident and emergency department with a history of being generally unwell for the preceding week and on examination is found to have cervical lymphadenopathy. In addition to a volley of tests, a Lactate Dehydrogenase (LDH) was requested by a registrar who had read that this was a predictor of malignancy which came back as 1,750. Should this be seen as suggestive of underlying malignancy?

Report by:

Tauseef Mehrali (SHO), Birmingham Children’s Hospital

How often have you seen a child with a neck full of lymph nodes, sent an LDH and been concerned about lymphoma? It’s a frequent occurrence in my clinical practise (although I am a Paeds Oncologists in between Archimedes topics). And I do fret about them – but should I be? (At a rough guess, my pre-test probability of lymphoma is about 75%; probably a fair bit higher than the ED experience.) What do the rest of you do, or think?

By submitting your comment you agree to adhere to these terms and conditions
You can follow any responses to this entry through the RSS 2.0 feed.
ADC blog homeapage

ADC Online

Education, debate, and meandering thoughts on child health, using evidence and research.Visit site



Creative Comms logo

Latest from Archives of Disease in Childhood

Latest from Archives of Disease in Childhood