Cortical atrophy, as assessed by novel volumetric MRI techniques, have revealed inconsistent results in ALS. Specifically, while cortical thinning, predominantly within the motor/frontal lobe regions, have been reported by some, absence of atrophy has been reported by others. Mioshi and colleagues elegantly demonstrate a potential explanation for such discordant MRI findings. Namely, ALS patients with […]
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MS and ALS: A common pathophysiological denominator?
Ismail and colleagues report on a high concurrence rate of multiple sclerosis (MS) and ALS. Interestingly, the C9orf72 expansion was identified in 80% of the ALS-MS patients. Given that the inflammatory system appears to be deregulated in patients expressing the c9orf72 expansion, with down-regulation of the neuroprotective CXCL10 chemokine and dysfunction of NF-kB activity, the […]