Cortical thickness: A biomarker of upper motor neuron dysfunction?

Thinning of the motor cortex has been suggested as a biomarker of cortical dysfunction in ALS, although the specificity of the finding remains to be determined. In an upcoming issue of JNNP Walhout and colleagues report on the fact that cortical thinning was a specific feature in ALS, related to pathology of upper motor neurons. Consequently, the possibility of cortical thickness measures serving as potential biomarkers of ALS remains very real.


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J Neurol Neurosurg Psychiatry doi:10.1136/jnnp-2013-306839
  • Neuromuscular
  • Research paper

Cortical thickness in ALS: towards a marker for upper motor neuron involvement

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