Thinning of the motor cortex has been suggested as a biomarker of cortical dysfunction in ALS, although the specificity of the finding remains to be determined. In an upcoming issue of JNNP Walhout and colleagues report on the fact that cortical thinning was a specific feature in ALS, related to pathology of upper motor neurons. Consequently, the possibility of cortical thickness measures serving as potential biomarkers of ALS remains very real.
Must read more at: http://jnnp.bmj.com/content/early/2014/08/13/jnnp-2013-306839.abstract
- Research paper