Glutamate and memory: A novel paradigm in MS

Posted on by Steve Vucic, Web Editor

Glutamate is a major excitatory  neurotransmitter in the human brain vital for multiple functions, including memory and cognition.  Importantly, excessive glutamate activity may be harmful

to the CNS, leading to neurodegeneration.  In this issue of JNNP, Muhlert and colleagues report a link between glutamate levels and memory, a unique link in MS.  Given that forgetfulness is a common symptom in MS, the possibility of using glutamate agonist, or enhancer of the glutamatergic system,   has real potential.

 

Read more at :  http://jnnp.bmj.com/content/85/8/833.abstract

Memory in multiple sclerosis is linked to glutamate concentration in grey matter regions

Open Access

  1. Nils Muhlert1,2,
  2. Matteo Atzori3,4,
  3. Enrico De Vita5,6,
  4. David L Thomas6,
  5. Rebecca S Samson1,
  6. Claudia A M Wheeler-Kingshott1,
  7. Jeroen J G Geurts7,
  8. David H Miller1,8,
  9. Alan J Thompson3,8,
  10. Olga Ciccarelli3,8

 

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