MS and Pregnancy: Control the disease before conception for good outcomes?

Pregnancy has been traditionally associated with lower frequency of relapses and more quiescent MS disease activity.  Consequently, cessation of medications is encouraged, and is necessary for some of the newer oral therapies.  In this issue of JNNP the Italisn MS group publish an important and elegant paper documenting that the control of disease post-partum is really dependent on what is occurring pre conception.  Fewer relapses before pregnancy and lower disability score 9perhpas reflecting less active disease) is associated with better outcomes, as is early resumption of disease modifying agents.




J Neurol Neurosurg Psychiatry 2014;85:845-850 doi:10.1136/jnnp-2013-306054
  • Multiple sclerosis
  • Research paper

Postpartum relapses increase the risk of disability progression in multiple sclerosis: the role of disease modifying drugs

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