Identification of Lynch syndrome among people newly diagnosed with endometrial cancer: a prospective audit (Contributed by Prof. Emma J Davidson)

The UK National Institute for Health and Care Excellence (NICE) recommends the unselected testing of all endometrial cancer patients for Lynch syndrome. This study found that while nearly all endometrial cancer patients discussed at a Gynaecological Cancer MDT in the North West of England were successfully screened for Lynch syndrome, not all high-risk individuals completed follow-up testing. Gynaecology-led, or “mainstreamed” genetic testing significantly accelerated diagnosis times compared to traditional clinical genetics referrals. Implementing this streamlined approach is essential to identify at-risk families up to twice as fast. (https://jmg.bmj.com/content/early/2026/05/28/jmg-2026-111578)

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