Functional and genetic epidemiological characterisation of the FFAR4 (GPR120) p.R270H variant in the Danish population

The 7TM receptor for long chain fatty acids FFAR4 (GPR120) currently attracts great attention as a therapeutic target to treat metabolic diseases. A low-frequency missense variant (p.R270H, rs116454156) in FFAR4 has previously been reported to associate with obesity in European populations and to impair signaling of the receptor. Here we further examine the functional consequences of p.R270H on receptor properties, and expand the human association studies by investigating traits of relevance for obesity- and glucose metabolism. Despite impaired effects on receptor function, we found no statistically significant associations with any examined traits. (By Marie Aare Vestmar, http://jmg.bmj.com/content/early/2016/04/11/jmedgenet-2015-103728 )

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