Continued lessons from the INS gene: an intronic mutation causing diabetes through a novel mechanism

Neonatal diabetes (diagnosed under 6 months of age) is usually caused by a disruption (mutation) in one of over twenty diabetes-related genes. One of the most common causes of neonatal diabetes is mutations in the insulin gene that result in production of a misshaped insulin protein that leads to death of the insulin producing beta cells. We describe a new type of mutation, deep in the non-coding part of the insulin gene, that causes diabetes through a previously undescribed mechanism. This discovery extends our understanding of diabetes and may have broader implications for those with insulin deficiency later in life. (By Dr. David Carmody, )

2B revised Tiff

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