The rs12975333 variant in the miR-125a and breast cancer risk in Germany, Italy, Australia and Spain

We all have the same genes; however, DNA mutations within genes, inherited from parents and transmitted to children, together with environmental factors, make us all different. Some mutations increase the risk of developing diseases with respect to general population. Recently, the mutation rs12975333 has been “associated with increased breast cancer risk” in the population of Antwerp, Belgium. We studied several thousands of persons from Germany, Italy, Australia and Spain and did not find anyone with the mutation. So, while rs12975333 may be responsible for breast cancer of some of the persons in Antwerp, it is absent in the other studied populations. (By Paolo Peterlongo, IFOM, )

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