Colorectal cancer susceptibility loci on chromosome 8q23.3 and 11q23.1 as modifiers for disease expression in lynch syndrome

Lynch syndrome confers a high lifetime risk of developing cancer, especially colorectal and endometrial cancer. Recently, six genomic regions have been identified that increase colorectal cancer (CRC) risk in the general population and two of these regions are associated with an increased risk of developing CRC in Lynch syndrome patients. The results of this study further confirmed that these two chromosomal regions (8q23.3 and 11q23) influenced the risk of developing CRC as well as the age of diagnosis of CRC in Lynch syndrome patients that have MLH1 mutations. (By Dr. Bente Talseth-Palmer, http://jmg.bmj.com/content/early/2010/11/19/jmg.2010.079962.abstract?papetoc )

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