Diagnostic pitfalls Here the authors discuss the difficulties in differentiating microbial (in particular tuberculous) causes of intrathoracic lymphadenopathy and sarcoidosis; indeed, sarcoidosis may occur in patients with previous microbial infection just as TB occurs in patients who are HLA B27 positive. Case reports are an excellent platform for diagnostic debate and the discussion of pitfalls. […]
Month: November 2011
Unilateral onycholysis in a patient taking erlotinib (Tarceva)
Rare side effect of treatment Here the authors present a case of unilateral onycholysis in a patient receiving an EGFR tyrosine kinase inhibitor. In addition to describing a possible mechanism for this side effect, the authors also highlight the benefits of targeted therapy. Seema Biswas Editor-in-Chief Unilateral onycholysis in a patient taking erlotinib (Tarceva) […]
The use of intraoperative PET probe to resect metastatic melanoma
Introducing novel methods of investigation and treatment Here the authors report two cases of metastatic melanoma resected with the assistance of an intraoperative handheld positron emission tomography (PET) probe. The probe was used to identify hypermetabolic lymph nodes and after resection the probe reading returned to background levels. At follow up the patients remained disease […]
Botulism cases in Scotland linked to jars of curry sauce
Botulism, due to food contaminated with Clostridium botulinum, is rare in the UK but two cases in one family in Scotland have led to the withdrawal of a particular batch of ‘Loyd Grossman Korma sauce’ by the Health Protection Agency over the weekend. http://www.hpa.org.uk/NewsCentre/NationalPressReleases/2011PressReleases/111113botulism/ […]
The place of case reports in medical literature: Periorbital cellulits – a mistaken diagnosis!
Case reports offer level IV evidence ranked well below randomised control trials and meta-analyses. http://healthpolicyandreform.nejm.org/?p=14876&query=TOC What role do case reports have then in the medical literature? Certainly, the report of adverse events, the opportunity to discuss diagnostic pitfalls, present novel methods of investigation and treatment and, of course, present cases of enormous interest and concern. […]
Pathology: Primary bladder amyloidosis
An 89 year old lady presents with painless haematuria and is found to have an extremely unusual lesion of the bladder. The pathology is discussed in detail and microscopy reveals stunning images… Seema Biswas Editor-in-Chief Primary bladder amyloidosis […]