April sees five new entries in the top 10 most read articles. Reaching number one this month is a systematic review of cohort studies by Ravnskov et al, which investigates the association between low-density-lipoprotein cholesterol (LDL-C) and mortality in the elderly. Results indicate that high LDL-C is inversely associated with mortality in most people aged over 60, questioning the validity of the cholesterol hypothesis. In light of their results, Ravnskov et al suggest that a re-evaluation of the guidelines recommending pharmacological reduction of LDL-C in the elderly is needed.
Palser et al are in at number three with a qualitative study exploring the views of people with cystic fibrosis, and those close to them, of their first experience of respiratory infection from Pseudomonas aeruginosa. Reaching number five is a systematic review assessing the evidence for the effectiveness of social prescribing. Bickerdike at al were not able to measure success or cost effectiveness due to limited detail in the data collected, but found that social prescribing is widely implemented and encouraged.
Also making its way into the top ten is a systematic review and meta-analysis by Whiting et al evaluating the risks and benefits of temporarily discontinuing medications to prevent acute kidney injury. Finally, at number 10 this month is a systematic review of systematic reviews by Abraha et el, which provides an overview of non-pharmacological interventions for behavioural and psychological symptoms in dementia (BPSD). Abraha et el found great variation in how the same treatments are applied and assessed and that conclude that music therapy and behavioural management treatments were effective for reducing BPSD.
*Most read figures are based on pdf downloads and full text views. Abstract views are excluded.